| Binding of heterocyclic aromatic amines by lactic acid bacteria: results of a comprehensive screening trial. | |
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MedLine Citation:
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PMID: 18320573 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Aim of the present study was a comprehensive investigation of the detoxification capacities of lactic acid bacteria (LAB) towards heterocyclic aromatic amines (HCA) formed during cooking of meat. It has been postulated that LAB prevent genotoxic and/or carcinogenic effects of HCA in laboratory rodents and humans via direct binding mechanisms. We measured the removal of the most abundant cooked food mutagens (AalphaC, PhIP, IQ, MeIQx, DiMeIQx) by eight LAB species. From each species, twelve strains were tested in liquid binding experiments with HPLC coupled with coulometric electrode array detection. The highest removal rates were observed with the representatives of the L. helveticus and S. thermophilus groups, which were seven to eight times more effective than L. kefir and L. plantarum. Strong and statistically significant differences were seen in the binding behaviour of the individual amines, the ranking order of detoxification being AalphaC > DiMeIQx > MeIQx > IQ > PhIP. Results of Salmonella/microsome assays with strain TA98 showed that the binding of AalphaC and PhIP to LAB correlates with the reduction of their mutagenic activities. This study may contribute to the development of strategies concerning the adverse health effects of HCA utilizing highly protective LAB for the production of fermented foods. |
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Authors:
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Reinhard Stidl; Gerhard Sontag; Verena Koller; Siegfried Knasmüller |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Molecular nutrition & food research Volume: 52 ISSN: 1613-4133 ISO Abbreviation: Mol Nutr Food Res Publication Date: 2008 Mar |
Date Detail:
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Created Date: 2008-03-10 Completed Date: 2008-04-10 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 101231818 Medline TA: Mol Nutr Food Res Country: Germany |
Other Details:
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Languages: eng Pagination: 322-9 Citation Subset: IM |
Affiliation:
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Department of Analytical and Food Chemistry, Faculty of Chemistry, University of Vienna, Austria. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anticarcinogenic Agents Antimutagenic Agents Carbolines / metabolism Carcinogens / metabolism* Food Handling / methods Heterocyclic Compounds / metabolism* Hot Temperature Imidazoles / metabolism Lactobacillus / metabolism* Meat / analysis Mutagenicity Tests Mutagens / metabolism* Quinolines / metabolism Quinoxalines / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Anticarcinogenic Agents; 0/Antimutagenic Agents; 0/Carbolines; 0/Carcinogens; 0/Heterocyclic Compounds; 0/Imidazoles; 0/Mutagens; 0/Quinolines; 0/Quinoxalines; 105650-23-5/2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine; 26148-68-5/2-amino-9H-pyrido(2,3-b)indole; 76180-96-6/2-amino-3-methylimidazo(4,5-f)quinoline; 77500-04-0/2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline; 95896-78-9/3,4,8-trimethylimidazo(4,5-f)quinoxalin-2-amine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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