Document Detail


Binding of heterocyclic aromatic amines by lactic acid bacteria: results of a comprehensive screening trial.
MedLine Citation:
PMID:  18320573     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Aim of the present study was a comprehensive investigation of the detoxification capacities of lactic acid bacteria (LAB) towards heterocyclic aromatic amines (HCA) formed during cooking of meat. It has been postulated that LAB prevent genotoxic and/or carcinogenic effects of HCA in laboratory rodents and humans via direct binding mechanisms. We measured the removal of the most abundant cooked food mutagens (AalphaC, PhIP, IQ, MeIQx, DiMeIQx) by eight LAB species. From each species, twelve strains were tested in liquid binding experiments with HPLC coupled with coulometric electrode array detection. The highest removal rates were observed with the representatives of the L. helveticus and S. thermophilus groups, which were seven to eight times more effective than L. kefir and L. plantarum. Strong and statistically significant differences were seen in the binding behaviour of the individual amines, the ranking order of detoxification being AalphaC > DiMeIQx > MeIQx > IQ > PhIP. Results of Salmonella/microsome assays with strain TA98 showed that the binding of AalphaC and PhIP to LAB correlates with the reduction of their mutagenic activities. This study may contribute to the development of strategies concerning the adverse health effects of HCA utilizing highly protective LAB for the production of fermented foods.
Authors:
Reinhard Stidl; Gerhard Sontag; Verena Koller; Siegfried Knasmüller
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Molecular nutrition & food research     Volume:  52     ISSN:  1613-4133     ISO Abbreviation:  Mol Nutr Food Res     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-03-10     Completed Date:  2008-04-10     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  101231818     Medline TA:  Mol Nutr Food Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  322-9     Citation Subset:  IM    
Affiliation:
Department of Analytical and Food Chemistry, Faculty of Chemistry, University of Vienna, Austria.
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MeSH Terms
Descriptor/Qualifier:
Anticarcinogenic Agents
Antimutagenic Agents
Carbolines / metabolism
Carcinogens / metabolism*
Food Handling / methods
Heterocyclic Compounds / metabolism*
Hot Temperature
Imidazoles / metabolism
Lactobacillus / metabolism*
Meat / analysis
Mutagenicity Tests
Mutagens / metabolism*
Quinolines / metabolism
Quinoxalines / metabolism
Chemical
Reg. No./Substance:
0/Anticarcinogenic Agents; 0/Antimutagenic Agents; 0/Carbolines; 0/Carcinogens; 0/Heterocyclic Compounds; 0/Imidazoles; 0/Mutagens; 0/Quinolines; 0/Quinoxalines; 105650-23-5/2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine; 26148-68-5/2-amino-9H-pyrido(2,3-b)indole; 76180-96-6/2-amino-3-methylimidazo(4,5-f)quinoline; 77500-04-0/2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline; 95896-78-9/3,4,8-trimethylimidazo(4,5-f)quinoxalin-2-amine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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