| Binding and action of glucagon in isolated adipocytes from cortisol-treated rats. | |
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MedLine Citation:
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PMID: 3036138 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Evidence for pre-receptor, receptor and post-receptor glucagon defects was investigated in adipocytes from cortisol-treated rats. A decrease in glucagon binding due to a decreased number of receptors was observed. No changes in receptor affinity were detected. Both, the lipolytic response of glucagon and the ability of glucagon to increase basal and theophylline-stimulated cAMP accumulation remained unaltered. Moreover, a hyperglucagonemia accompanied by an increase in glucagon degradation in the serum of cortisol-treated rats was observed. Such alterations could represent a new mechanism by which glucocorticoids exert their biological actions. |
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Authors:
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C Calle; P Sanchez-Casas; M A Simón; P Mayor |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 145 ISSN: 0006-291X ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 1987 May |
Date Detail:
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Created Date: 1987-07-15 Completed Date: 1987-07-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 90-5 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue
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drug effects,
metabolism* Animals Glucagon / metabolism*, pharmacology Hydrocortisone / pharmacology* Kinetics Male Rats Rats, Inbred Strains Receptors, Gastrointestinal Hormone / drug effects, metabolism* Receptors, Glucagon Theophylline / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Gastrointestinal Hormone; 0/Receptors, Glucagon; 50-23-7/Hydrocortisone; 58-55-9/Theophylline; 9007-92-5/Glucagon |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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