Document Detail


CCAAT/Enhancer-Binding Protein α Negatively Regulates IFN-γ Expression in T Cells.
MedLine Citation:
PMID:  25398328     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Humoral immunity, including Ab switching and somatic hypermutation, is critically regulated by CD4(+) T cells. T follicular helper (Tfh) cells have been recently shown to be a distinct T cell subset important in germinal center reactions. The transcriptional regulation of Tfh cell development and function has not been well understood. In this study, we report that C/EBPα, a basic region/leucine zipper transcription factor, is highly expressed in Tfh cells. Cebpa-deficient CD4(+) T cells exhibit enhanced IFN-γ expression in vitro and in vivo. T cell-specific Cebpa knockout mice, although not defective in Tfh cell generation, produce significantly increased levels of IgG2a/b and IgG3 following immunization with a protein Ag. Moreover, C/EBPα binds to the Ifng gene and inhibits T-bet-driven Ifng transcription in a DNA binding-dependent manner. Our study thus demonstrates that C/EBPα restricts IFN-γ expression in T cells to allow proper class switching by B cells.
Authors:
Shinya Tanaka; Kentaro Tanaka; Fay Magnusson; Yeonseok Chung; Gustavo J Martinez; Yi-Hong Wang; Roza I Nurieva; Tomohiro Kurosaki; Chen Dong
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Publication Detail:
Type:  Journal Article     Date:  2014-11-14
Journal Detail:
Title:  Journal of immunology (Baltimore, Md. : 1950)     Volume:  193     ISSN:  1550-6606     ISO Abbreviation:  J. Immunol.     Publication Date:  2014 Dec 
Date Detail:
Created Date:  2014-12-06     Completed Date:  -     Revised Date:  2014-12-06    
Medline Journal Info:
Nlm Unique ID:  2985117R     Medline TA:  J Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  6152-60     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2014 by The American Association of Immunologists, Inc.
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MeSH Terms
Descriptor/Qualifier:
Grant Support
ID/Acronym/Agency:
R01 AI106654/AI/NIAID NIH HHS

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