| Binder phenotype in mothers affected with auto-immune disorders. | |
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MedLine Citation:
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PMID: 22082304 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Abstract Objective: To report four foetal cases of the Binder phenotype associated with maternal autoimmune disorders. Patients and Methods: In three mothers with autoimmune diseases, 2D and 3D ultrasonographic measurements were made on four foetuses with the Binder profile, and were compared with postnatal phenotypes. Results: The Binder phenotype can be detected in early pregnancy (14.5 WG). All foetuses had verticalized nasal bones and midfacial hypoplasia. Punctuate calcifications were found in almost all the cases. No specific maternal auto-antibody has been associated with foetal Binder phenotype. Conclusion: Since the Binder phenotype can be diagnosed at ultrasound examination during pregnancy, it is important to establish the underlying cause so as to assess the foetal prognosis. This study stresses the importance of systematic checks for maternal autoimmune disease in cases of prenatally diagnosed Binder phenotypes. |
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Authors:
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Estelle Colin; Marion Gerard-Blanluet; Sylvie Odent; Dominique Bonneau; Renaud Touraine; Jean-Marc Levaillant; Laurent Pasquier; Fran Oise Boussion; Mathilde Ferry; Agn S Guichet; Magalie Barth; Antoine Mercier |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-14 |
Journal Detail:
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Title: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians Volume: - ISSN: 1476-4954 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101136916 Medline TA: J Matern Fetal Neonatal Med Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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University Hospital Angers, Clinical Genetic Department, IBS, all?e du pont, angers, 49933 cedex 9 France. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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