| Bimodal relationship between sinus node arterial distension and sinus nodal automaticity. | |
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MedLine Citation:
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PMID: 7282938 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the isolated buffer perfused canine sinus node the effect of either an increase or decrease in perfusion rate (PR), and hence sinus node (SN) arterial pressure (PSNA), on the frequency of sinus nodal depolarization (SDF) is bimodal. SDF decreased from 121.9 +/- 6.1 to 101.4 +/- 6.0 depolarizations/min as PR and PSNA increased from 1 to 4 ml/min and from 18.7 +/- 3.8 to 45.1 +/- 7.3 mmHg, respectively. Further increasing PR from 4 to 10 ml/mn (PSNA increasing from 45.1 +/- 7.3 to 94.0 +/- 14.1 mmHg) caused SDF to increase from 101.4 +/- 6.0 to 121.0 +/- 7.4 depolarizations/min. With respect to the PR, SDF is logarithmically related to the relative degree to which the SN artery is distended, the degree of SN arterial distension being determined by the change in SN arterial resistance (R) with respect to PR (dR/dPR). This relationship is defined by the equation: SDF = 9.23 1n(--dR/dPR) + 99.7. While these results support the existence of a mechanism for autoregulation of sinus nodal automaticity, they indicate that it is considerably more complex than previously envisioned. |
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Authors:
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G E Musgrave |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of physiology Volume: 241 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1981 Sep |
Date Detail:
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Created Date: 1981-11-18 Completed Date: 1981-11-18 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: H311-6 Citation Subset: IM; S |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Coronary Circulation Dogs Female Male Mechanoreceptors / physiology Myocardial Contraction Perfusion Pressure Sinoatrial Node / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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GM-07014/GM/NIGMS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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