| Bimodal oscillation frequencies of blood flow in the inflammatory colon microcirculation. | |
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MedLine Citation:
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PMID: 18951508 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Rhythmic changes in blood flow direction have been described in the mucosal plexus of mice with acute colitis. In this report, we studied mice with acute colitis induced either by dextran sodium sulfate or by trinitrobenzenesulfonic acid. Both forms of colitis were associated with blood flow oscillations as documented by fluorescence intravital videomicroscopy. The complex oscillation patterns suggested more than one mechanism for these changes in blood flow. By tracking fluorescent nanoparticles in the inflamed mucosal plexus, we identified two forms of blood flow oscillations within the inflammatory mouse colon. Stable oscillations were associated with a base frequency of approximately 2 cycles/sec. Velocity measurements in the upstream and downstream vessel segments indicated that stable oscillations were the result of regional flow occlusion within the mucosal plexus. In contrast, metastable oscillations demonstrated a lower frequency (0.2-0.4 cycles/sec) and appeared to be the result of flow dynamics in vessels linked by the bridging mucosal vessels. These blood flow oscillations were not directly associated with cardiopulmonary movement. We conclude that both the stable and metasable oscillating patterns reflect flow adaptations to inflammatory changes in the mucosal plexus. Anat Rec, 2009. (c) 2008 Wiley-Liss, Inc. |
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Authors:
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Akira Tsuda; Aslihan Turhan; Moritz Konerding; Dino Ravnic; Dusan Hanidziar; Miao Lin; Steven J Mentzer |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Anatomical record (Hoboken, N.J. : 2007) Volume: 292 ISSN: 1932-8494 ISO Abbreviation: Anat Rec (Hoboken) Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2009-01-13 Completed Date: 2009-11-09 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 101292775 Medline TA: Anat Rec (Hoboken) Country: United States |
Other Details:
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Languages: eng Pagination: 65-72 Citation Subset: IM |
Affiliation:
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Molecular and Integrative Physiological Sciences, Harvard School of Public Health, Boston, Massachusetts, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Clocks* / physiology Blood Flow Velocity* / physiology Colitis / pathology*, physiopathology Colon / blood supply, pathology* Inflammation / pathology, physiopathology Male Mice Mice, Inbred BALB C Microcirculation* / physiology Regional Blood Flow* / physiology |
| Grant Support | |
ID/Acronym/Agency:
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HL47078/HL/NHLBI NIH HHS; HL75426/HL/NHLBI NIH HHS; R01 HL094567-01A1/HL/NHLBI NIH HHS; R01 HL094567-02/HL/NHLBI NIH HHS |
| Comments/Corrections | |
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