Document Detail


Bimodal oscillation frequencies of blood flow in the inflammatory colon microcirculation.
MedLine Citation:
PMID:  18951508     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Rhythmic changes in blood flow direction have been described in the mucosal plexus of mice with acute colitis. In this report, we studied mice with acute colitis induced either by dextran sodium sulfate or by trinitrobenzenesulfonic acid. Both forms of colitis were associated with blood flow oscillations as documented by fluorescence intravital videomicroscopy. The complex oscillation patterns suggested more than one mechanism for these changes in blood flow. By tracking fluorescent nanoparticles in the inflamed mucosal plexus, we identified two forms of blood flow oscillations within the inflammatory mouse colon. Stable oscillations were associated with a base frequency of approximately 2 cycles/sec. Velocity measurements in the upstream and downstream vessel segments indicated that stable oscillations were the result of regional flow occlusion within the mucosal plexus. In contrast, metastable oscillations demonstrated a lower frequency (0.2-0.4 cycles/sec) and appeared to be the result of flow dynamics in vessels linked by the bridging mucosal vessels. These blood flow oscillations were not directly associated with cardiopulmonary movement. We conclude that both the stable and metasable oscillating patterns reflect flow adaptations to inflammatory changes in the mucosal plexus. Anat Rec, 2009. (c) 2008 Wiley-Liss, Inc.
Authors:
Akira Tsuda; Aslihan Turhan; Moritz Konerding; Dino Ravnic; Dusan Hanidziar; Miao Lin; Steven J Mentzer
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Anatomical record (Hoboken, N.J. : 2007)     Volume:  292     ISSN:  1932-8494     ISO Abbreviation:  Anat Rec (Hoboken)     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-01-13     Completed Date:  2009-11-09     Revised Date:  2014-09-19    
Medline Journal Info:
Nlm Unique ID:  101292775     Medline TA:  Anat Rec (Hoboken)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  65-72     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Biological Clocks* / physiology
Blood Flow Velocity* / physiology
Colitis / pathology*,  physiopathology
Colon / blood supply,  pathology*
Inflammation / pathology,  physiopathology
Male
Mice
Mice, Inbred BALB C
Microcirculation* / physiology
Regional Blood Flow* / physiology
Grant Support
ID/Acronym/Agency:
HL47078/HL/NHLBI NIH HHS; HL75426/HL/NHLBI NIH HHS; R01 HL094567/HL/NHLBI NIH HHS; R01 HL094567-01A1/HL/NHLBI NIH HHS; R01 HL094567-02/HL/NHLBI NIH HHS
Comments/Corrections

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