Document Detail

Bimodal distribution of V beta 2+CD4+ T cells in human peripheral blood.
MedLine Citation:
PMID:  8149954     Owner:  NLM     Status:  MEDLINE    
The distribution of T cells using the V beta 2 gene was studied in a group of 99 humans. The distribution of V beta 2+CD4+ levels was bimodal. Twelve individuals had levels of V beta 2+CD4+ less than 2% and 86 others had values greater than 5%. Only one individual had a value between 2% and 5%. The V beta 2 low (mean 1.3 +/- 0.49) and V beta 2 high (mean 8.2 +/- 1.65) phenotypes were stable. The V beta 2 low phenotype is inherited and not limited to HLA or T cell receptor V beta gene complexes. The CD8V beta 2 levels of CD4V beta 2 low individuals are also low. The residual V beta 2+ T cells in V beta 2 low individuals were not anergic to V beta 2-specific stimulation. These data are compatible with the effects of an endogenous superantigen.
G R Clarke; H Reyburn; F C Lancaster; A W Boylston
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of immunology     Volume:  24     ISSN:  0014-2980     ISO Abbreviation:  Eur. J. Immunol.     Publication Date:  1994 Apr 
Date Detail:
Created Date:  1994-05-09     Completed Date:  1994-05-09     Revised Date:  2009-09-29    
Medline Journal Info:
Nlm Unique ID:  1273201     Medline TA:  Eur J Immunol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  837-42     Citation Subset:  IM    
Molecular Medicine Unit, University of Leeds.
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MeSH Terms
Antigens, CD4 / analysis*
Base Sequence
Middle Aged
Molecular Sequence Data
Receptors, Antigen, T-Cell, alpha-beta / analysis,  genetics*
Superantigens / immunology
T-Lymphocyte Subsets / immunology*
Grant Support
//Wellcome Trust
Reg. No./Substance:
0/Antigens, CD4; 0/Receptors, Antigen, T-Cell, alpha-beta; 0/Superantigens

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