Document Detail

Bimodal cardiac dysfunction in an animal model of iron overload.
MedLine Citation:
PMID:  12389025     Owner:  NLM     Status:  MEDLINE    
Iron-overload cardiomyopathy is the most common cause of death in patients with thalassemia major, yet the associated changes in cardiac function have not been quantified. We studied the effects of iron overload on cardiac function in Mongolian gerbils, a species that responds to iron overload in the same manner as human beings. We injected iron-dextran or dextran alone at low subcutaneous doses (200 mg/kg/wk) for 20 to 60 weeks and at high doses (800 mg/kg/wk) for 6 to 20 weeks. At shorter durations for either dose, the mean values of cardiac work, coronary flow, left ventricular (dP/dt)(max) and left ventricular (dP/dt)(min) in isolated perfused hearts were significantly greater than control values; at longer durations, these values were significantly less than control values. Echocardiography in intact animals showed eccentric cardiac hypertrophy, increased cardiac output, and normal exercise tolerance at shorter durations of dosage. At longer durations, concentric cardiac hypertrophy developed, and cardiac output and exercise capacity were impaired. The response to iron overload in Mongolian gerbils progresses from an initial state of high cardiac output to a subsequent state of low-output failure similar to the course of cardiomyopathy that has been inferred in patients with transfusional iron overload.
Tianen Yang; Wei-Qiang Dong; Yuri A Kuryshev; Carlos Obejero-Paz; Matthew N Levy; Gary M Brittenham; Songsak Kiatchoosakun; Darryl Kirkpatrick; Brian D Hoit; Arthur M Brown
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of laboratory and clinical medicine     Volume:  140     ISSN:  0022-2143     ISO Abbreviation:  J. Lab. Clin. Med.     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-10-21     Completed Date:  2002-11-05     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375375     Medline TA:  J Lab Clin Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  263-71     Citation Subset:  AIM; IM    
Rammelkamp Center for Education and Research, MetroHealth Campus, 2500 MetroHealth Drive R301, Cleveland, OH 44109-1998, USA.
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MeSH Terms
Cardiac Output
Cardiomyopathies / etiology*,  physiopathology*,  ultrasonography
Coronary Circulation
Disease Models, Animal
Iron / administration & dosage
Iron Overload / complications*,  physiopathology*
Myocardial Contraction
beta-Thalassemia / complications,  physiopathology
Grant Support
Reg. No./Substance:
Comment In:
J Lab Clin Med. 2002 Oct;140(4):295-6   [PMID:  12395802 ]
J Lab Clin Med. 2004 Feb;143(2):130-2; author reply 133-4   [PMID:  14966469 ]
J Lab Clin Med. 2003 Jun;141(6):419-20; author reply 420-2   [PMID:  12819640 ]

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