Document Detail


Bimodal thrombus imaging: simultaneous PET/MR imaging with a fibrin-targeted dual PET/MR probe--feasibility study in rat model.
MedLine Citation:
PMID:  21177389     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To image thrombus by using magnetic resonance (MR) imaging and positron emission tomography (PET) simultaneously in a rat arterial thrombus model with a dual PET/MR probe.
MATERIALS AND METHODS: Animal studies were approved by the institutional animal use committee. A dual PET/MR probe was synthesized by means of partial exchange of gadolinium for copper 64 ((64)Cu) in the fibrin-targeted MR probe EP-2104R. A preformed 25-mm thrombus was injected into the right internal carotid artery of a rat. Imaging was performed with a clinical 3.0-T MR imager with an MR-compatible human PET imager. Rats (n = 5) were imaged prior to and after systemic administration of the dual probe by using simultaneous PET/MR. The organ distribution of (64)Cu and gadolinium was determined ex vivo (n = 8), 2 hours after injection by using well counting and inductively coupled plasma mass spectrometry, respectively. Signal intensity ratios (SIRs) between the thrombus-containing and contralateral vessel were computed from PET images and MR data before and after probe administration.
RESULTS: The dual probe was synthesized with greater than 98% radiochemical purity. Thrombus enhancement was observed in all five animals at both MR (SIR([postprobe])/SIR([preprobe]) = 1.71 ± 0.35, P = .0053) and PET (SIR = 1.85 ± 0.48, P = .0087) after injection of the dual PET/MR probe. Ex vivo analysis at 2 hours after injection showed the highest (64)Cu and gadolinium concentrations, after the excretory organs (kidney and liver), to be in the thrombus.
CONCLUSION: A fibrin-targeted dual PET/MR probe enables simultaneous, direct MR and PET imaging of thrombus.
Authors:
Ritika Uppal; Ciprian Catana; Ilknur Ay; Thomas Benner; A Gregory Sorensen; Peter Caravan
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-12-21
Journal Detail:
Title:  Radiology     Volume:  258     ISSN:  1527-1315     ISO Abbreviation:  Radiology     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-02-22     Completed Date:  2011-06-02     Revised Date:  2014-09-15    
Medline Journal Info:
Nlm Unique ID:  0401260     Medline TA:  Radiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  812-20     Citation Subset:  AIM; IM    
Copyright Information:
© RSNA, 2010.
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MeSH Terms
Descriptor/Qualifier:
Animals
Chromatography, High Pressure Liquid
Contrast Media / diagnostic use
Feasibility Studies
Fibrin
Gadolinium / diagnostic use
Heterocyclic Compounds / diagnostic use
Magnetic Resonance Imaging / methods*
Mass Spectrometry
Organometallic Compounds / diagnostic use
Peptides / diagnostic use
Positron-Emission Tomography / methods*
Rats
Thrombosis / diagnosis*,  radionuclide imaging
Grant Support
ID/Acronym/Agency:
5T32CA009502/CA/NCI NIH HHS; EB009062/EB/NIBIB NIH HHS; EB009783/EB/NIBIB NIH HHS; NS38477/NS/NINDS NIH HHS; P41-RR14075/RR/NCRR NIH HHS; R01 EB009062/EB/NIBIB NIH HHS; R21 EB009738/EB/NIBIB NIH HHS
Chemical
Reg. No./Substance:
0/Contrast Media; 0/EP-2104R; 0/Heterocyclic Compounds; 0/Organometallic Compounds; 0/Peptides; 9001-31-4/Fibrin; 92923-44-9/gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate; AU0V1LM3JT/Gadolinium
Comments/Corrections

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