| Bim and Bmf in tissue homeostasis and malignant disease. | |
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MedLine Citation:
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PMID: 19641506 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Among all BH3-only proteins known to date, most information is available on the biological role and function of Bim (Bcl-2 interacting mediator of cell death)/BOD (Bcl-2 related ovarian death agonist), whereas little is still known about its closest relative, Bcl-2 modifying factor (Bmf). Although Bim has been implicated in the regulation of cell death induction in multiple cell types and tissues in response to a large number of stimuli, including growth factor or cytokine deprivation, calcium flux, ligation of antigen receptors on T and B cells, glucocorticoid or loss of adhesion, Bmf seems to play a more restricted role by supporting Bim in some of these cell death processes. This review aims to highlight similarities between Bim and Bmf function in apoptosis signaling and their role in normal development and disease. |
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Authors:
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J D Piñon; V Labi; A Egle; A Villunger |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Oncogene Volume: 27 Suppl 1 ISSN: 1476-5594 ISO Abbreviation: Oncogene Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2009-07-30 Completed Date: 2009-09-21 Revised Date: 2012-02-06 |
Medline Journal Info:
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Nlm Unique ID: 8711562 Medline TA: Oncogene Country: England |
Other Details:
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Languages: eng Pagination: S41-52 Citation Subset: IM |
Affiliation:
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Laboratory for Immunological and Molecular Cancer Research, University Hospital Salzburg, Salzburg, Austria. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adaptor Proteins, Signal Transducing
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chemistry,
genetics,
physiology* Animals Apoptosis / drug effects, physiology* Apoptosis Regulatory Proteins / chemistry, genetics, physiology* Autoimmune Diseases / metabolism Gene Expression Regulation Gene Targeting Homeostasis / physiology* Humans Lymphocytes / cytology Membrane Proteins / chemistry, genetics, physiology* Mice Mice, Knockout Mitochondria / metabolism Neoplasm Proteins / physiology* Neoplasms / metabolism, pathology, therapy Proteasome Endopeptidase Complex / metabolism Protein Isoforms / physiology Protein Structure, Tertiary Proto-Oncogene Proteins / chemistry, genetics, physiology* Proto-Oncogene Proteins c-bcl-2 / antagonists & inhibitors Tumor Suppressor Proteins / chemistry, genetics, physiology |
| Grant Support | |
ID/Acronym/Agency:
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F 2110//Austrian Science Fund FWF; Y 212-B12//Austrian Science Fund FWF |
| Chemical | |
Reg. No./Substance:
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0/Adaptor Proteins, Signal Transducing; 0/Apoptosis Regulatory Proteins; 0/BMF protein, human; 0/Bcl-2-like protein 11; 0/Membrane Proteins; 0/Neoplasm Proteins; 0/Protein Isoforms; 0/Proto-Oncogene Proteins; 0/Proto-Oncogene Proteins c-bcl-2; 0/Tumor Suppressor Proteins; EC 3.4.25.1/Proteasome Endopeptidase Complex |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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