Document Detail


Bim and Bmf in tissue homeostasis and malignant disease.
MedLine Citation:
PMID:  19641506     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Among all BH3-only proteins known to date, most information is available on the biological role and function of Bim (Bcl-2 interacting mediator of cell death)/BOD (Bcl-2 related ovarian death agonist), whereas little is still known about its closest relative, Bcl-2 modifying factor (Bmf). Although Bim has been implicated in the regulation of cell death induction in multiple cell types and tissues in response to a large number of stimuli, including growth factor or cytokine deprivation, calcium flux, ligation of antigen receptors on T and B cells, glucocorticoid or loss of adhesion, Bmf seems to play a more restricted role by supporting Bim in some of these cell death processes. This review aims to highlight similarities between Bim and Bmf function in apoptosis signaling and their role in normal development and disease.
Authors:
J D Piñon; V Labi; A Egle; A Villunger
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Oncogene     Volume:  27 Suppl 1     ISSN:  1476-5594     ISO Abbreviation:  Oncogene     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2009-07-30     Completed Date:  2009-09-21     Revised Date:  2013-06-02    
Medline Journal Info:
Nlm Unique ID:  8711562     Medline TA:  Oncogene     Country:  England    
Other Details:
Languages:  eng     Pagination:  S41-52     Citation Subset:  IM    
Affiliation:
Laboratory for Immunological and Molecular Cancer Research, University Hospital Salzburg, Salzburg, Austria.
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MeSH Terms
Descriptor/Qualifier:
Adaptor Proteins, Signal Transducing / chemistry,  genetics,  physiology*
Animals
Apoptosis / drug effects,  physiology*
Apoptosis Regulatory Proteins / chemistry,  genetics,  physiology*
Autoimmune Diseases / metabolism
Gene Expression Regulation
Gene Targeting
Homeostasis / physiology*
Humans
Lymphocytes / cytology
Membrane Proteins / chemistry,  genetics,  physiology*
Mice
Mice, Knockout
Mitochondria / metabolism
Neoplasm Proteins / physiology*
Neoplasms / metabolism,  pathology,  therapy
Proteasome Endopeptidase Complex / metabolism
Protein Isoforms / physiology
Protein Structure, Tertiary
Proto-Oncogene Proteins / chemistry,  genetics,  physiology*
Proto-Oncogene Proteins c-bcl-2 / antagonists & inhibitors
Tumor Suppressor Proteins / chemistry,  genetics,  physiology
Grant Support
ID/Acronym/Agency:
F 2110//Austrian Science Fund FWF; Y 212-B12//Austrian Science Fund FWF
Chemical
Reg. No./Substance:
0/Adaptor Proteins, Signal Transducing; 0/Apoptosis Regulatory Proteins; 0/BMF protein, human; 0/Bcl-2-like protein 11; 0/Membrane Proteins; 0/Neoplasm Proteins; 0/Protein Isoforms; 0/Proto-Oncogene Proteins; 0/Proto-Oncogene Proteins c-bcl-2; 0/Tumor Suppressor Proteins; EC 3.4.25.1/Proteasome Endopeptidase Complex
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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