Document Detail


Bilobalide prevents reduction of gamma-aminobutyric acid levels and glutamic acid decarboxylase activity induced by 4-O-methylpyridoxine in mouse hippocampus.
MedLine Citation:
PMID:  12659176     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We previously reported that bilobalide, a constituent of Ginkgo biloba L. leaves, protected mice against convulsions induced by 4-O-methylpyridoxine (MPN). To elucidate the mechanism of the anticonvulsant activity of bilobalide, this study examined the effect of bilobalide on MPN-induced changes in the levels of gamma-aminobutyric acid (GABA) and glutamate, and in the activity of glutamic acid decarboxylase (GAD) in the hippocampus, cerebral cortex and striatum of the mouse. GABA levels and GAD activity in the hippocampus and cerebral cortex were significantly enhanced by bilobalide treatment (30 mg/kg, p.o., for 4 days) alone. MPN significantly decreased GABA levels and GAD activity in the three brain regions tested compared with those in the control. Pretreatment with bilobalide effectively suppressed the MPN-induced reduction in GABA levels and GAD activity in the hippocampus and cerebral cortex. On the other hand, there were no significant differences in the glutamate levels in the three regions despite various treatments. These results suggested that bilobalide prevents MPN-induced reduction in GABA levels through potentiation by bilobalide of GAD activity, and this effect of bilobalide contributes to its anticonvulsant effect against MPN-induced convulsions.
Authors:
K Sasaki; S Hatta; K Wada; H Ohshika; M Haga
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Life sciences     Volume:  67     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2003-03-27     Completed Date:  2003-04-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  709-15     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, School of Medicine, Sapporo Medical University, South 1, West 17, Chuo-ku, Sapporo 060-8556, Japan. ksasaki@hoku-iryo-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Animals
Cerebral Cortex / drug effects,  enzymology,  metabolism
Cyclopentanes / pharmacology*
Diterpenes*
Furans / pharmacology*
Ginkgo biloba / chemistry*
Ginkgolides
Glutamate Decarboxylase / metabolism*
Glutamic Acid / metabolism
Hippocampus / drug effects,  enzymology,  metabolism*
Male
Mice
Neostriatum / drug effects,  enzymology,  metabolism
Nerve Tissue Proteins / metabolism
Pyridoxine / analogs & derivatives*,  antagonists & inhibitors*,  pharmacology*
gamma-Aminobutyric Acid / metabolism*
Chemical
Reg. No./Substance:
0/Cyclopentanes; 0/Diterpenes; 0/Furans; 0/Ginkgolides; 0/Nerve Tissue Proteins; 1464-33-1/4-methoxymethylpyridoxine; 33570-04-6/bilobalide; 56-12-2/gamma-Aminobutyric Acid; 56-86-0/Glutamic Acid; 65-23-6/Pyridoxine; EC 4.1.1.15/Glutamate Decarboxylase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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