| Bilirubin production and the risk of bilirubin neurotoxicity. | |
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MedLine Citation:
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PMID: 21641484 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Neonatal jaundice usually occurs in the transitional period after birth, presenting as an elevation of circulating bilirubin. Bilirubin neurotoxicity can occur if the levels of bilirubin become excessive (hyperbilirubinemia). This pathologic phenotype of newborn jaundice can develop because of excessive bilirubin production or impaired conjugation, with the risk for developing bilirubin-induced neurologic dysfunction, depending on the degree of the resultant bilirubin load. The plasma bilirubin level thus can be used to assess an infant's risk for developing bilirubin neurotoxicity relative to an infant's age in hours. Because all infants have an impaired conjugation ability, infants at greatest risk are those who have increased bilirubin production rates, because of hemolysis, for example. Therefore, developing potential preventive strategies as well as noninvasive technologies to treat and to identify infants with increased bilirubin production rates, respectively, are tantamount to reducing the incidence of bilirubin-induced neurologic dysfunction. |
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Authors:
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David K Stevenson; Hendrik J Vreman; Ronald J Wong |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Seminars in perinatology Volume: 35 ISSN: 1558-075X ISO Abbreviation: Semin. Perinatol. Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-06-06 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7801132 Medline TA: Semin Perinatol Country: United States |
Other Details:
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Languages: eng Pagination: 121-6 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Pediatrics, Stanford University School of Medicine, Stanford, CA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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