Document Detail


Bilirubin production and the risk of bilirubin neurotoxicity.
MedLine Citation:
PMID:  21641484     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Neonatal jaundice usually occurs in the transitional period after birth, presenting as an elevation of circulating bilirubin. Bilirubin neurotoxicity can occur if the levels of bilirubin become excessive (hyperbilirubinemia). This pathologic phenotype of newborn jaundice can develop because of excessive bilirubin production or impaired conjugation, with the risk for developing bilirubin-induced neurologic dysfunction, depending on the degree of the resultant bilirubin load. The plasma bilirubin level thus can be used to assess an infant's risk for developing bilirubin neurotoxicity relative to an infant's age in hours. Because all infants have an impaired conjugation ability, infants at greatest risk are those who have increased bilirubin production rates, because of hemolysis, for example. Therefore, developing potential preventive strategies as well as noninvasive technologies to treat and to identify infants with increased bilirubin production rates, respectively, are tantamount to reducing the incidence of bilirubin-induced neurologic dysfunction.
Authors:
David K Stevenson; Hendrik J Vreman; Ronald J Wong
Related Documents :
15644504 - Bayes factor analysis for the genetic background of physiological and vitality variable...
9127064 - The effects of a neonatal positioner on scapular rotation.
12381544 - The pathophysiology of aldosterone in the cardiovascular system.
4087114 - Analysis of neonatal heart rate variability by a microprocessor-based on-line system.
24044524 - Perinatal mortality following assisted reproductive technology treatment in australia a...
22727874 - Improved survival among children with spina bifida in the united states.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Seminars in perinatology     Volume:  35     ISSN:  1558-075X     ISO Abbreviation:  Semin. Perinatol.     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-06-06     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7801132     Medline TA:  Semin Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  121-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Affiliation:
Department of Pediatrics, Stanford University School of Medicine, Stanford, CA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Bilirubin injury to neurons and glial cells: new players, novel targets, and newer insights.
Next Document:  Assessment of UGT polymorphisms and neonatal jaundice.