| Bilirubin, intraventricular hemorrhage, and phenobarbital in very low birth weight babies. | |
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MedLine Citation:
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PMID: 3405664 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The relationships among serum bilirubin concentration on days 5 and 7, birth weight, the presence of intraventricular hemorrhage, and the receipt of phenobarbital were examined in a group of 232 newborns weighing less than 1,751 g who were intubated, mechanically ventilated by 12 hours after birth, and whose parents had given permission for a randomized trial of phenobarbital prophylaxis of intraventricular hemorrhage. The ratio of serum bilirubin concentration to birth weight (the bilirubin divided by birth weight index [BBI]) was used to examine the impact of 25 variables on a clinical guideline for therapy of hyperbilirubinemia in newborn infants. A linear regression model was used; the most powerful covariate was a birth weight less than 1.0 kg. The only other variable that reduced the BBI was phenobarbital receipt. The presence of intraventricular hemorrhage and ecchymoses had a significant influence increasing the BBI. |
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Authors:
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M F Epstein; A Leviton; K C Kuban; M Pagano; C Meltzer; H N Skouteli; E R Brown; K F Sullivan |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Pediatrics Volume: 82 ISSN: 0031-4005 ISO Abbreviation: Pediatrics Publication Date: 1988 Sep |
Date Detail:
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Created Date: 1988-09-22 Completed Date: 1988-09-22 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0376422 Medline TA: Pediatrics Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 350-4 Citation Subset: AIM; IM |
Affiliation:
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Department of Newborn Medicine, Brigham and Women's Hospital, Boston, MA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bilirubin
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blood* Birth Weight Cerebral Hemorrhage / blood*, prevention & control Humans Infant, Low Birth Weight* Infant, Newborn Phenobarbital / therapeutic use* |
| Grant Support | |
ID/Acronym/Agency:
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NS 20807/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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50-06-6/Phenobarbital; 635-65-4/Bilirubin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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