Document Detail

Biliary physiology and disease: reflections of a physician-scientist.
MedLine Citation:
PMID:  20373364     Owner:  NLM     Status:  MEDLINE    
A review is presented of Gustav Paumgartner's five decades of research and practice in hepatology focusing on biliary physiology and disease. It begins with studies of the excretory function of the liver including hepatic uptake of indocyanine green, bilirubin, and bile acids. The implications of these studies for diagnosis and understanding of liver diseases are pointed out. From there, the path of scientific research leads to investigations of hepatobiliary bile acid transport and the major mechanisms of bile formation. The therapeutic effects of the hydrophilic bile acid, ursodeoxycholic acid, have greatly stimulated these studies. Although ursodeoxycholic acid therapy for dissolution of cholesterol gallstones and some other nonsurgical treatments of gallstones were largely superseded by surgical techniques, ursodeoxycholic acid is currently considered the mainstay of therapy of some chronic cholestatic liver diseases, such as primary biliary cirrhosis. The major mechanisms of action of ursodeoxycholic acid therapy in cholestatic liver diseases are discussed. An attempt is made to illustrate how scientific research can lead to advances in medical practice that help patients.
Gustav Paumgartner
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  51     ISSN:  1527-3350     ISO Abbreviation:  Hepatology     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-07     Completed Date:  2010-04-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1095-106     Citation Subset:  IM    
Department of Medicine II, Klinikum Grosshadern, University of Munich, Munich, Germany.
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MeSH Terms
Bile / physiology*,  secretion
Bile Acids and Salts / metabolism
Cholestasis / drug therapy*
Gallstones / therapy*
Indocyanine Green / metabolism
Liver / metabolism
Ursodeoxycholic Acid / therapeutic use*
Reg. No./Substance:
0/Bile Acids and Salts; 128-13-2/Ursodeoxycholic Acid; 3599-32-4/Indocyanine Green

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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