| Biliary physiology and disease: reflections of a physician-scientist. | |
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MedLine Citation:
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PMID: 20373364 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A review is presented of Gustav Paumgartner's five decades of research and practice in hepatology focusing on biliary physiology and disease. It begins with studies of the excretory function of the liver including hepatic uptake of indocyanine green, bilirubin, and bile acids. The implications of these studies for diagnosis and understanding of liver diseases are pointed out. From there, the path of scientific research leads to investigations of hepatobiliary bile acid transport and the major mechanisms of bile formation. The therapeutic effects of the hydrophilic bile acid, ursodeoxycholic acid, have greatly stimulated these studies. Although ursodeoxycholic acid therapy for dissolution of cholesterol gallstones and some other nonsurgical treatments of gallstones were largely superseded by surgical techniques, ursodeoxycholic acid is currently considered the mainstay of therapy of some chronic cholestatic liver diseases, such as primary biliary cirrhosis. The major mechanisms of action of ursodeoxycholic acid therapy in cholestatic liver diseases are discussed. An attempt is made to illustrate how scientific research can lead to advances in medical practice that help patients. |
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Authors:
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Gustav Paumgartner |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Hepatology (Baltimore, Md.) Volume: 51 ISSN: 1527-3350 ISO Abbreviation: Hepatology Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-07 Completed Date: 2010-04-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8302946 Medline TA: Hepatology Country: United States |
Other Details:
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Languages: eng Pagination: 1095-106 Citation Subset: IM |
Affiliation:
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Department of Medicine II, Klinikum Grosshadern, University of Munich, Munich, Germany. Gustav.Paumgartner@med.uni-muenchen.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bile / physiology*, secretion Bile Acids and Salts / metabolism Cholestasis / drug therapy* Gallstones / therapy* Humans Indocyanine Green / metabolism Liver / metabolism Recurrence Ursodeoxycholic Acid / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Bile Acids and Salts; 128-13-2/Ursodeoxycholic Acid; 3599-32-4/Indocyanine Green |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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