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Biliary phosphatidylcholine and lysophosphatidylcholine profiles in sclerosing cholangitis.
MedLine Citation:
PMID:  24023488     Owner:  NLM     Status:  In-Data-Review    
AIM: To analyze phospholipid profiles in intrahepatic bile from patients with primary sclerosing cholangitis (PSC) and secondary sclerosing cholangitis (SSC).
METHODS: Intrahepatic bile specimens collected via endoscopic retrograde cholangiography from 41 patients were analyzed. Fourteen of these patients were diagnosed with PSC, 10 with SSC, 11 with choledocholithiasis or no identifiable biliary disease, and 6 with cholangiocellular carcinoma (CCC). Bile acid, cholesterol, protein, and bilirubin contents as well as pancreas lipase activity in bile were determined by biochemical methods. Phosphatidylcholine (PC) and lysophosphatidylcholine (LPC) species were quantified using nano-electrospray ionization tandem mass spectrometry.
RESULTS: Bile from all the examined patient groups showed a remarkably similar PC and LPC species composition, with only minor statistical differences. Total biliary PC concentrations were highest in controls (8030 ± 1843 μmol/L) and lowest in patients with CCC (1969 ± 981 μmol/L) (P = 0.005, controls vs SSC and CCC, respectively, P < 0.05). LPC contents in bile were overall low (4.2% ± 1.8%). Biliary LPC/PC ratios and ratios of biliary PC to bilirubin, PC to cholesterol, PC to protein, and PC to bile acids showed no intergroup differences.
CONCLUSION: PC and LPC profiles being similar in patients with or without sclerosing cholangitis, these phospholipids are likely not of major pathogenetic importance in this disease group.
Annika Gauss; Robert Ehehalt; Wolf-Dieter Lehmann; Gerhard Erben; Karl-Heinz Weiss; Yvonne Schaefer; Petra Kloeters-Plachky; Adolf Stiehl; Wolfgang Stremmel; Peter Sauer; Daniel Nils Gotthardt
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  World journal of gastroenterology : WJG     Volume:  19     ISSN:  1007-9327     ISO Abbreviation:  World J. Gastroenterol.     Publication Date:  2013 Sep 
Date Detail:
Created Date:  2013-09-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100883448     Medline TA:  World J Gastroenterol     Country:  China    
Other Details:
Languages:  eng     Pagination:  5454-63     Citation Subset:  IM    
Annika Gauss, Robert Ehehalt, Karl-Heinz Weiss, Yvonne Schaefer, Petra Kloeters-Plachky, Adolf Stiehl, Wolfgang Stremmel, Peter Sauer, Daniel Nils Gotthardt, Gastroenterology and Hepatology Unit, Department of Internal Medicine, University Hospital Heidelberg, 69120 Heidelberg, Germany.
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