Document Detail


Biliary pharmacokinetics of ticarcillin and clavulanic acid.
MedLine Citation:
PMID:  3722048     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The biliary excretion of ticarcillin and clavulanic acid was studied in 26 patients who required elective biliary surgery. In patients with normal hepatic function or unconjugated hyperbilirubinaemia the mean concentrations of ticarcillin in bile from common bile ducts and functioning gall bladders exceeded the mean concentration in plasma and bile from gall bladders with poor or absent function. Concentrations of ticarcillin in the walls of gall bladders were comparable regardless of function. In patients with obstructive jaundice, concentrations of ticarcillin in bile and the wall of gall bladders were lower than the concentrations in plasma. In all patients the mean concentrations of clavulanic acid in the biliary samples were invariably lower than the mean concentration in plasma.
Authors:
A W Owen; E B Faragher
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Journal of antimicrobial chemotherapy     Volume:  17 Suppl C     ISSN:  0305-7453     ISO Abbreviation:  J. Antimicrob. Chemother.     Publication Date:  1986 May 
Date Detail:
Created Date:  1986-07-25     Completed Date:  1986-07-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7513617     Medline TA:  J Antimicrob Chemother     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  65-70     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Bile / analysis
Biliary Tract / metabolism*
Cholelithiasis / metabolism*,  physiopathology,  surgery
Cholestasis, Extrahepatic / metabolism
Clavulanic Acids / metabolism*,  therapeutic use
Drug Combinations / metabolism,  therapeutic use
Gallbladder / analysis,  physiopathology
Humans
Kinetics
Penicillins / metabolism*
Premedication
Spherocytosis, Hereditary / metabolism
Ticarcillin / metabolism*,  therapeutic use
Chemical
Reg. No./Substance:
0/Clavulanic Acids; 0/Drug Combinations; 0/Penicillins; 34787-01-4/Ticarcillin; 86482-18-0/ticarcillin-clavulanic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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