Document Detail

Biliary immunoreactive trypsin in man.
MedLine Citation:
PMID:  3038717     Owner:  NLM     Status:  MEDLINE    
Small, but significant amounts of immunoreactive trypsin/trypsinogen (IRT) are excreted in bile, obtained via percutaneous transhepatic catheter in patients with complete distal bile duct obstruction, and thus uncontaminated with pancreatic juice. The major serum proteolytic enzyme inhibitors alpha 2-macroglobulin and alpha 1-antitrypsin are also present in very small amounts in bile. The bile-to-serum ratios of these inhibitors are much lower (approximately two orders of magnitude) than that for IRT. The role of these inhibitors and their relative importance in biliary proteolytic enzyme inhibition is unknown.
G Lake-Bakaar; J Dooley
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hepato-gastroenterology     Volume:  34     ISSN:  0172-6390     ISO Abbreviation:  Hepatogastroenterology     Publication Date:  1987 Jun 
Date Detail:
Created Date:  1987-08-28     Completed Date:  1987-08-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8007849     Medline TA:  Hepatogastroenterology     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  103-5     Citation Subset:  IM    
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MeSH Terms
Adenoma, Bile Duct / metabolism
Bile / metabolism*
Common Bile Duct Neoplasms / metabolism
Middle Aged
Pancreatic Neoplasms / metabolism
Trypsin / metabolism*
Trypsinogen / metabolism
Reg. No./Substance:
9002-08-8/Trypsinogen; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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