Document Detail

Biliary excretion of inorganic electrolytes: its role in hepatic bile formation.
MedLine Citation:
PMID:  4075249     Owner:  NLM     Status:  MEDLINE    
To define the role of inorganic electrolyte secretion in hepatic bile formation, the effects of secretin, glucagon, and differently structured bile acids on bile flow and composition were studied in the dog, guinea pig, and rat. In the dog and guinea pig, secretin (2.5-10 clinical units X kg-1 X 30 min-1) increased bile flow and bicarbonate concentration in bile, a finding consistent with the hypothesis that the hormone stimulates a bicarbonate-dependent secretion possibly at the level of the bile ductule-duct. In the rat, secretin (5-15 CU X kg-1 X 30 min-1) failed to increase bile secretion. Glucagon (1.25-300 micrograms X kg-1 X 30 min-1) increased bile flow in all the three species, and produced no changes in biliary bicarbonate concentrations in the dog and rat. In the guinea pig, however, glucagon choleresis was associated with an increase in bicarbonate concentration in bile, similar to that observed with secretin. The choleretic activities of various bile acids (taurocholate, chenodeoxycholate, glycochenodeoxycholate, tauroursodeoxycholate, and ursodeoxycholic acid, infused at 30-360 mumol X kg-1 X 30 min-1) were similar in the rat (6.9-7.2 microL/mumol), but different in the guinea pig (11-31 microL/mumol). In the latter species, the more hydrophobic the bile acid, the greater was its choleretic activity. In all instances, bile acid choleresis was associated with a decline in the biliary concentrations of chloride, but with no major change in bicarbonate levels.(ABSTRACT TRUNCATED AT 250 WORDS)
N Tavoloni
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Canadian journal of physiology and pharmacology     Volume:  63     ISSN:  0008-4212     ISO Abbreviation:  Can. J. Physiol. Pharmacol.     Publication Date:  1985 Oct 
Date Detail:
Created Date:  1986-02-17     Completed Date:  1986-02-17     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0372712     Medline TA:  Can J Physiol Pharmacol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  1245-51     Citation Subset:  IM    
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MeSH Terms
Bile / metabolism*
Bile Acids and Salts / pharmacology
Electrolytes / metabolism*
Glucagon / pharmacology
Guinea Pigs
Liver / metabolism*
Rats, Inbred Strains
Secretin / pharmacology
Species Specificity
Taurocholic Acid / pharmacology
Grant Support
Reg. No./Substance:
0/Bile Acids and Salts; 0/Electrolytes; 1393-25-5/Secretin; 81-24-3/Taurocholic Acid; 9007-92-5/Glucagon

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