Document Detail

Biliary excretion disorders in infants: evaluation using 99mTc PIPIDA.
MedLine Citation:
PMID:  6771998     Owner:  NLM     Status:  MEDLINE    
A new class of hepatobiliary imaging agents has become available--the N-substituted iminodiacetic acids. After intravenous administration, these compounds are quickly extracted by the hepatocytes and rapidly excreted into the biliary tree. By using a 99mTc label, sufficient activity may be given to allow excellent gamma-camera imaging, 99mTc-labeled p-isopropylacetanilido-iminodiacetic acid (PIPIDA) has been used in the evaluation of infants with biliary excretion disorders, including two infants with neonatal hepatitis, three with intrahepatic cholestatic jaundice, and 10 with biliary atresia. Follow-up evaluation of surgically created portoenterostomies has been performed as well. In comparison with the previously available agent (131I rose bengal), the marked reduction in radiation to the liver alone should predicate the use of 99mTc PIPIDA. In addition, the speed of handling of this agent by the liver and the vastly improved imaging statistics make 99mTc PIPIDA a desirable agent for the evaluation of biliary excretion disorders in infancy.
J H Miller; F R Sinatra; D W Thomas
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  AJR. American journal of roentgenology     Volume:  135     ISSN:  0361-803X     ISO Abbreviation:  AJR Am J Roentgenol     Publication Date:  1980 Jul 
Date Detail:
Created Date:  1980-09-26     Completed Date:  1980-09-26     Revised Date:  2008-02-15    
Medline Journal Info:
Nlm Unique ID:  7708173     Medline TA:  AJR Am J Roentgenol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  47-52     Citation Subset:  AIM; IM    
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MeSH Terms
Bile Ducts / abnormalities*
Biliary Tract Diseases / radionuclide imaging*
Child, Preschool
Cholestasis, Intrahepatic / radionuclide imaging
Evaluation Studies as Topic
Hepatitis / radionuclide imaging
Imino Acids / diagnostic use*
Organotechnetium Compounds*
Technetium / diagnostic use*
Reg. No./Substance:
0/Imino Acids; 0/Organotechnetium Compounds; 0/technetium Tc 99m PIPIDA; 7440-26-8/Technetium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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