Document Detail


Biliary excretion of [14C]temazepam and its metabolites in the rat.
MedLine Citation:
PMID:  6132989     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The excretion of temazepam and its N-desmethyl metabolite, oxazepam, and their respective O-conjugates was examined following a single intravenous dose of [14C]temazepam to two groups of bile fistula rats, with and without bile replenishment to the animals via duodenal cannulae. During an 8-hr collection period, the two groups produced virtually identical bile volumes, and there were no significant differences between them in the amount of total radioactivity, free temazepam, or the identified metabolites in the bile, as determined by TLC and liquid scintillation counting. Elimination of the radioactive dose was rapid during 0-8 hr, with a half-life of approximately 1 hr. Approximately 85-90% of the administered radioactivity was recovered in the bile: less than 1% as free temazepam, 3% as oxazepam, and approximately 10% as their O-conjugates.
Authors:
F L Tse; F Ballard; J M Jaffe
Related Documents :
4036339 - Rapid thin-layer chromatographic screening method for the detection of five sulfonamide...
2757659 - Metabolism and excretion of 14c-tiropramide after single intravenous or peroral adminis...
11370699 - Tissue distribution of radioactivity following intranasal administration of radioactive...
12385899 - Uptake, clearance and metabolism of tegdma in guinea pigs.
20538719 - The dipeptidyl peptidase-4 inhibitor linagliptin exhibits time- and dose-dependent loca...
17454559 - Disposition and clearance of tungsten after single-dose oral and intravenous exposure i...
11483779 - Antibody protects macaques against vaginal challenge with a pathogenic r5 simian/human ...
9183359 - Glycine site antagonist attenuates infarct size in experimental focal ischemia. postmor...
23184569 - Effect of spironolactone and amiloride on thiazolidinedione-induced fluid retention in ...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pharmaceutical sciences     Volume:  72     ISSN:  0022-3549     ISO Abbreviation:  J Pharm Sci     Publication Date:  1983 Mar 
Date Detail:
Created Date:  1983-06-10     Completed Date:  1983-06-10     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  2985195R     Medline TA:  J Pharm Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  311-2     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Anxiety Agents / metabolism*
Bile / metabolism*
Biotransformation
Chromatography, Thin Layer
Male
Rats
Rats, Inbred Strains
Temazepam / metabolism*
Chemical
Reg. No./Substance:
0/Anti-Anxiety Agents; 846-50-4/Temazepam

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Hypophysectomy does not prevent increased cerebral dopamine turnover following sulpiride administrat...
Next Document:  Effects of pirenzepine and atropine on vagal and cholinergic gastric secretion and gastrin release a...