Document Detail

Biliary excretion of [14C]temazepam and its metabolites in the rat.
MedLine Citation:
PMID:  6132989     Owner:  NLM     Status:  MEDLINE    
The excretion of temazepam and its N-desmethyl metabolite, oxazepam, and their respective O-conjugates was examined following a single intravenous dose of [14C]temazepam to two groups of bile fistula rats, with and without bile replenishment to the animals via duodenal cannulae. During an 8-hr collection period, the two groups produced virtually identical bile volumes, and there were no significant differences between them in the amount of total radioactivity, free temazepam, or the identified metabolites in the bile, as determined by TLC and liquid scintillation counting. Elimination of the radioactive dose was rapid during 0-8 hr, with a half-life of approximately 1 hr. Approximately 85-90% of the administered radioactivity was recovered in the bile: less than 1% as free temazepam, 3% as oxazepam, and approximately 10% as their O-conjugates.
F L Tse; F Ballard; J M Jaffe
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pharmaceutical sciences     Volume:  72     ISSN:  0022-3549     ISO Abbreviation:  J Pharm Sci     Publication Date:  1983 Mar 
Date Detail:
Created Date:  1983-06-10     Completed Date:  1983-06-10     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  2985195R     Medline TA:  J Pharm Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  311-2     Citation Subset:  IM    
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MeSH Terms
Anti-Anxiety Agents / metabolism*
Bile / metabolism*
Chromatography, Thin Layer
Rats, Inbred Strains
Temazepam / metabolism*
Reg. No./Substance:
0/Anti-Anxiety Agents; 846-50-4/Temazepam

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