| Biliary excretion of 110mAg and its kinetics in the isolated perfused liver in rats. | |
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MedLine Citation:
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PMID: 3722809 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The biliary excretion of 110mAg in rats after i.v. administration of an aqueous solution of 110mAgNO3 (4.57 micrograms; 16kBq per rat) was studied for a period of 24 hours. The maximum rate of excretion was reached in 30th minute after the metal administration and over 70% of the silver dosed was excreted during 24 hours. Using the method of isolated perfused liver it was observed that 110mAg is rapidly taken up in the liver. During the five minutes period of the perfusion less than 50% of silver administered was found in the perfusion medium. In following minutes the level of the metal in the medium remained approximately constant. It was suggested that the rate of excretion of silver and its high uptake in the liver tissue is in connection with an unusual binding of it in the bile. |
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Authors:
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P Tichý; J Rosina; K Bláha; M Cikrt |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Journal of hygiene, epidemiology, microbiology, and immunology Volume: 30 ISSN: 0022-1732 ISO Abbreviation: J Hyg Epidemiol Microbiol Immunol Publication Date: 1986 |
Date Detail:
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Created Date: 1986-08-14 Completed Date: 1986-08-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2985116R Medline TA: J Hyg Epidemiol Microbiol Immunol Country: CZECHOSLOVAKIA |
Other Details:
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Languages: eng Pagination: 145-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bile / metabolism* Female Kinetics Liver / metabolism* Perfusion Rats Rats, Inbred Strains Silver / metabolism* |
| Chemical | |
Reg. No./Substance:
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7440-22-4/Silver |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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