| Biliary brush cytology and the detection of cholangiocarcinoma in primary sclerosing cholangitis: evaluation of specific cytomorphologic features and CA19-9 levels. | |
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MedLine Citation:
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PMID: 16191503 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Interpreting biliary brush cytology (BBC) findings in primary sclerosing cholangitis (PSC) is problematic. In our study, BBC findings and CA19-9 serum levels were evaluated for their effectiveness in diagnosing cholangiocarcinoma in patients with PSC. We reviewed 107 biliary brushings from 51 patients with PSC and concurrent CA19-9 levels between January 1995 and March 2004 at the University of Washington Medical Center, Seattle. A portion of the brushings were evaluated and scored according to specific cytologic criteria; statistical analysis showed which criteria were most predictive in diagnosing malignancy: nuclear/cytoplasmic ratio, prominent nucleoli, nuclear membrane irregularities, and discohesion were significant predictive features. Sensitivity and specificity of BBC were 62.5% and 100%, respectively. Sensitivity and specificity of CA19-9 at a cutoff of 186 IU/mL were 100% and 94%, respectively. BBC is a specific and relatively sensitive method of detecting cholangiocarcinoma, even in patients with PSC, especially when certain cytomorphologic features are identified. Combining biliary cytology and CA19-9 levels might have an important diagnostic role in PSC. |
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Authors:
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Paul S Furmanczyk; Verena S Grieco; S Nicholas Agoff |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of clinical pathology Volume: 124 ISSN: 0002-9173 ISO Abbreviation: Am. J. Clin. Pathol. Publication Date: 2005 Sep |
Date Detail:
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Created Date: 2005-09-29 Completed Date: 2005-10-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370470 Medline TA: Am J Clin Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 355-60 Citation Subset: AIM; IM |
Affiliation:
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University of Washington, School of Medicine, Seattle, WA 98111, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bile Duct Neoplasms
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blood,
pathology* Bile Ducts, Intrahepatic / pathology* CA-19-9 Antigen / blood* Cholangiocarcinoma / blood, pathology* Cholangitis, Sclerosing / blood, pathology* Female Humans Male Middle Aged Sensitivity and Specificity |
| Chemical | |
Reg. No./Substance:
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0/CA-19-9 Antigen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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