Document Detail


Biliary bile acids in primary biliary cirrhosis: effect of ursodeoxycholic acid.
MedLine Citation:
PMID:  10347103     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Bile acid composition in fasting duodenal bile was assessed at entry and at 2 years in patients with primary biliary cirrhosis (PBC) enrolled in a randomized, double-blind, placebo-controlled trial of ursodeoxycholic acid (UDCA) (10-12 mg/kg/d) taken as a single bedtime dose. Specimens were analyzed by a high-pressure liquid chromatography method that had been validated against gas chromatography. Percent composition in bile (mean +/- SD) for 98 patients at entry for cholic (CA), chenodeoxycholic (CDCA), deoxycholic (DCA), lithocholic (LCA), and ursodeoxycholic (UDCA) acids, respectively, were 57.4 +/- 18.6, 31.5 +/- 15.5, 8.0 +/- 9.3, 0.3 +/- 1.0, and 0.6 +/- 0.9. Values for CA were increased, whereas those for CDCA, DCA, LCA, and UDCA were decreased when compared with values in normal persons. Bile acid composition of the major bile acids did not change after 2 years on placebo medication. By contrast, in patients receiving UDCA for 2 years, bile became enriched with UDCA on average to 40.1%, and significant decreases were noted for CA (to 32.2%) and CDCA (to 19.5%). No change in percent composition was observed for DCA and LCA. Percent composition at entry and changes in composition after 2 years on UDCA were similar in patients with varying severity of PBC. In patients whose bile was not enriched in UDCA (entry and placebo-treated specimens), CA, CDCA, DCA, and the small amount of UDCA found in some of these specimens were conjugated to a greater extent with glycine (52%-64%) than with taurine (36%-48%). Treatment with UDCA caused the proportion of all endogenous bile acids conjugated with glycine to increase to 69% to 78%, while the proportion conjugated with taurine (22%-31%) fell (P <.05). Administered UDCA was also conjugated predominantly with glycine (87%).
Authors:
B Combes; R L Carithers; W C Maddrey; S Munoz; G Garcia-Tsao; G F Bonner; J L Boyer; V A Luketic; M L Shiffman; M G Peters; H White; R K Zetterman; R Risser; S S Rossi; A F Hofmann
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  29     ISSN:  0270-9139     ISO Abbreviation:  Hepatology     Publication Date:  1999 Jun 
Date Detail:
Created Date:  1999-06-22     Completed Date:  1999-06-22     Revised Date:  2014-06-15    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1649-54     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Bile / secretion*
Bile Acids and Salts / analysis*
Chenodeoxycholic Acid / analysis
Cholic Acid / analysis
Chromatography, Gas / methods
Chromatography, High Pressure Liquid / methods
Deoxycholic Acid / analysis
Double-Blind Method
Drug Administration Schedule
Female
Humans
Lithocholic Acid / analysis
Liver Cirrhosis, Biliary / drug therapy*,  metabolism*
Male
Middle Aged
Placebos
Regression Analysis
Reproducibility of Results
Time Factors
Ursodeoxycholic Acid / administration & dosage,  therapeutic use*
Grant Support
ID/Acronym/Agency:
M01 RR000036/RR/NCRR NIH HHS; M01 RR000633/RR/NCRR NIH HHS; M01-RR00633/RR/NCRR NIH HHS; MO1-RR00065/RR/NCRR NIH HHS; MO1-RR00125/RR/NCRR NIH HHS; R01 DK046602/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Bile Acids and Salts; 0/Placebos; 005990WHZZ/Deoxycholic Acid; 0GEI24LG0J/Chenodeoxycholic Acid; 5QU0I8393U/Lithocholic Acid; 724L30Y2QR/Ursodeoxycholic Acid; G1JO7801AE/Cholic Acid
Comments/Corrections

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