Document Detail


Bile and stone analysis in two infants with brown pigment gallstones and infected bile.
MedLine Citation:
PMID:  2642880     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Two infants under 3 mo of age who presented with obstructive jaundice secondary to cholelithiasis are reported. Neither infant had any congenital anatomic abnormality of the biliary tract leading to stasis, yet both had cultures of gallbladder bile that grew abundant bacteria. In both, recovery of gallbladder bile and sludge or actual stones allowed a detailed analysis of bile and stone composition. Bile was not saturated with cholesterol. In both cases, unconjugated bilirubin accounted for a large percentage of the total bile biliary pigments measured, and stercobilin was present in gallbladder bile. Bile beta-glucuronidase activity was higher when measured at the optimal pH of bacterial rather than tissue beta-glucuronidase. Analysis of stone morphology and composition showed characteristics of brown pigment gallstones with a layered appearance and the presence of calcium palmitate. This is the first report of detailed bile and stone analysis in infants and supports the hypothesis that brown pigment gallstones form spontaneously in infants who have bacterial infections in the biliary tract.
Authors:
W R Treem; P F Malet; G R Gourley; J S Hyams
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Gastroenterology     Volume:  96     ISSN:  0016-5085     ISO Abbreviation:  Gastroenterology     Publication Date:  1989 Feb 
Date Detail:
Created Date:  1989-02-22     Completed Date:  1989-02-22     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0374630     Medline TA:  Gastroenterology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  519-23     Citation Subset:  AIM; IM    
Affiliation:
Department of Pediatrics, University of Connecticut School of Medicine, Hartford.
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MeSH Terms
Descriptor/Qualifier:
Bile / metabolism*,  microbiology
Biliary Tract Diseases / complications*,  microbiology
Cholelithiasis / complications,  metabolism*,  pathology
Chromatography, High Pressure Liquid
Gallbladder / metabolism
Humans
Infant
Infant, Newborn
Infection / complications,  microbiology
Male
Pigmentation*
Ultrasonography
Grant Support
ID/Acronym/Agency:
AM010777/AM/NIADDK NIH HHS; HD03352/HD/NICHD NIH HHS; HD20914/HD/NICHD NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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