Document Detail

Bile secretory function: a determinant of adriamycin disposition.
MedLine Citation:
PMID:  7406604     Owner:  NLM     Status:  MEDLINE    
Adriamycin (ADR) is rapidly cleared from plasma and enters tissues, while it is extensively eliminated in bile and moderately in urine following i.v. injection of 20 mg/kg to anesthetized rats. In bile duct- and bladder-cannulated rats with physiologic bile and urine production, 26.6% of the injected ADR is excreted in bile as total ADR equivalents during a 3 hr period and 4.4% in urine. When the elimination of the drug in urine is prevented by ligation of the kidneys, no significant differences are observed in the disposition of the total drug equivalents. Conversely, when bile flow is inhibited by the administration of sodium taurolithocholate, the biliary excretion of the total ADR equivalents declines significantly and in a fashion related to the degree of bile flow reduction. In parallel with the diminished biliary elimination, the urinary excretion increases significantly and is responsible for most of the drug eliminated when severe cholestasis is produced. However, despite the increased urinary excretion, the overall elimination of the total ADR equivalents in cholestatic rats is significantly reduced and both plasma and tissue levels of the total drug equivalents rise significantly and in a fashion closely related to the degree of the induced cholestasis.
N Tavoloni; A M Guarino
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives internationales de pharmacodynamie et de thérapie     Volume:  245     ISSN:  0003-9780     ISO Abbreviation:  Arch Int Pharmacodyn Ther     Publication Date:  1980 Jun 
Date Detail:
Created Date:  1980-10-27     Completed Date:  1980-10-27     Revised Date:  2012-01-12    
Medline Journal Info:
Nlm Unique ID:  0405353     Medline TA:  Arch Int Pharmacodyn Ther     Country:  BELGIUM    
Other Details:
Languages:  eng     Pagination:  180-97     Citation Subset:  IM    
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MeSH Terms
Bile / metabolism*
Bile Ducts / physiology
Cholestasis / metabolism
Doxorubicin / blood,  metabolism*,  urine
Time Factors
Tissue Distribution
Urinary Bladder / physiology
Reg. No./Substance:

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