| Bile salts and cholestasis. | |
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MedLine Citation:
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PMID: 20434968 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Bile salts have a crucial role in hepatobiliary and intestinal homeostasis and digestion. Primary bile salts are synthesized by the liver from cholesterol, and may be modified by the intestinal flora to form secondary and tertiary bile salts. Bile salts are efficiently reabsorbed from the intestinal lumen to undergo enterohepatic circulation. In addition to their function as a surfactant involved in the absorption of dietary lipids and fat-soluble vitamins bile salts are potent signaling molecules in both the liver and intestine. Under physiological conditions the bile salt pool is tightly regulated, but the adaptive capacity may fall short under cholestatic conditions. Elevated serum and tissue levels of potentially toxic hydrophobic bile salts during cholestasis may cause mitochondrial damage, apoptosis or necrosis in susceptible cell types. Therapeutic nontoxic bile salts may restore impaired hepatobiliary secretion in cholestatic disorders. The hydrophilic bile salt ursodeoxycholate is today regarded as the effective standard treatment of primary biliary cirrhosis and intrahepatic cholestasis of pregnancy, and is implicated for use in various other cholestatic conditions. Novel therapeutic bile salts that are currently under evaluation may also prove valuable in the treatment of these diseases. |
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Authors:
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Lucas Maillette de Buy Wenniger; Ulrich Beuers |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver Volume: 42 ISSN: 1878-3562 ISO Abbreviation: Dig Liver Dis Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-14 Completed Date: 2010-10-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100958385 Medline TA: Dig Liver Dis Country: Netherlands |
Other Details:
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Languages: eng Pagination: 409-18 Citation Subset: IM |
Copyright Information:
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Copyright 2010. Published by Elsevier Ltd. |
Affiliation:
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Department of Gastroenterology and Hepatology, Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, University of Amsterdam, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis Bile Acids and Salts / metabolism* Bile Ducts / metabolism, pathology* Biological Transport, Active Cholestasis* / etiology, metabolism, pathology Disease Progression Hepatocytes / metabolism, pathology* Humans Intestinal Absorption / physiology |
| Chemical | |
Reg. No./Substance:
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0/Bile Acids and Salts |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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