Document Detail


Bile salt export pump is dysregulated with altered farnesoid X receptor isoform expression in patients with hepatocellular carcinoma.
MedLine Citation:
PMID:  23213087     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CONCLUSION: BSEP expression is severely diminished in HCC patients associated with alteration of FXR isoform expression induced by inflammation. Restoration of BSEP expression through suppressing inflammation in the liver may reestablish bile acid homeostasis.
Authors:
Yuan Chen; Xiulong Song; Leila Valanejad; Alexander Vasilenko; Vijay More; Xi Qiu; Weikang Chen; Yurong Lai; Angela Slitt; Matthew Stoner; Bingfang Yan; Ruitang Deng
Related Documents :
12595897 - Autoimmune regulator: from loss of function to autoimmunity.
23117887 - Pnuts functions as a proto-oncogene by sequestering pten.
24803537 - Downstream of mutant kras, the transcription regulator yap is essential for neoplastic ...
23305207 - Low cyclin f expression in hepatocellular carcinoma associates with poor differentiatio...
18413597 - Adenovirus e1a targets p400 to induce the cellular oncoprotein myc.
8832987 - Increased expression of transforming growth factor-beta1, fibronectin, and types i, iii...
Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article; Research Support, N.I.H., Extramural     Date:  2013-02-15
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  57     ISSN:  1527-3350     ISO Abbreviation:  Hepatology     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-04-09     Completed Date:  2013-07-05     Revised Date:  2014-04-02    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1530-41     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 American Association for the Study of Liver Diseases.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
ATP-Binding Cassette Transporters / metabolism*
Animals
Bile Acids and Salts / metabolism
Carcinoma, Hepatocellular / genetics,  metabolism*
Cell Line, Tumor
Disease Models, Animal
Female
Gene Expression Regulation, Neoplastic / genetics*
Homeostasis
Humans
Interleukin-6 / metabolism
Liver Neoplasms / genetics,  metabolism*
Mice
Mice, Inbred Strains
Protein Isoforms / genetics,  metabolism
Receptors, Cytoplasmic and Nuclear / genetics,  metabolism*
Tumor Necrosis Factor-alpha / metabolism
Grant Support
ID/Acronym/Agency:
K22 ES013782/ES/NIEHS NIH HHS; K22ES013782/ES/NIEHS NIH HHS; P20-RR016457/RR/NCRR NIH HHS; R01 DK087755/DK/NIDDK NIH HHS; R01DK087755/DK/NIDDK NIH HHS; R01ES016042/ES/NIEHS NIH HHS; R01ES07965/ES/NIEHS NIH HHS; R01GM61988/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/ABCB11 protein, human; 0/Bile Acids and Salts; 0/Interleukin-6; 0/Protein Isoforms; 0/Receptors, Cytoplasmic and Nuclear; 0/Tumor Necrosis Factor-alpha; 0/farnesoid X-activated receptor
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Vitamin A deficiency is associated with HCV chronic infection and with unresponsiveness to interfero...
Next Document:  Effect of patient socioeconomic status on access to early-phase cancer trials.