Document Detail

Bile-induced secretion of glucagon-like peptide-1: pathophysiological implications in type 2 diabetes?
MedLine Citation:
PMID:  20424139     Owner:  NLM     Status:  MEDLINE    
During the last decades it has become clear that bile acids not only act as simple fat solubilizers, but additionally represent complex hormonal metabolic integrators. Bile acids activate both nuclear receptors (controlling transcription of genes involved in for example bile acid, cholesterol, and glucose metabolism) and the cell surface G protein-coupled receptor TGR5 (modulating energy expenditure in brown fat and muscle cells). It has been shown that TGR5 is expressed in enteroendocrine L cells, which secrete the potent glucose-lowering incretin hormone glucagon-like peptide-1 (GLP-1). Recently it was shown that bile acid-induced activation of TGR5 results in intestinal secretion of GLP-1 and that enhanced TGR5 signaling improves postprandial glucose tolerance in diet-induced obese mice. This Perspectives article presents these novel findings in the context of prior studies on nutrient-induced GLP-1 secretion and outlines the potential implications of bile acid-induced GLP-1 secretion in physiological, pathophysiological, and pharmacological perspectives.
Filip K Knop
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Publication Detail:
Type:  Journal Article; Review     Date:  2010-04-27
Journal Detail:
Title:  American journal of physiology. Endocrinology and metabolism     Volume:  299     ISSN:  1522-1555     ISO Abbreviation:  Am. J. Physiol. Endocrinol. Metab.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-14     Completed Date:  2010-07-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100901226     Medline TA:  Am J Physiol Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  E10-3     Citation Subset:  IM    
Department of Internal Medicine F, Gentofte Hospital, University of Copenhagen, Niels Andersens Vej 65, Hellerup, Denmark.
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MeSH Terms
Bile Acids and Salts / physiology*
Diabetes Mellitus, Type 2 / physiopathology*
Glucagon-Like Peptide 1 / physiology*,  secretion
Obesity / physiopathology*
Postprandial Period / physiology
Receptors, G-Protein-Coupled / physiology
Reg. No./Substance:
0/Bile Acids and Salts; 0/GPBAR1 protein, human; 0/Receptors, G-Protein-Coupled; 89750-14-1/Glucagon-Like Peptide 1

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