| Bile ductular cells undergoing cellular senescence increase in chronic liver diseases along with fibrous progression. | |
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MedLine Citation:
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PMID: 20093230 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We investigated the pathologic significance of ductular reactions in chronic liver diseases with respect to cellular senescence. The expression of senescence-associated markers (p16(INK4a) and p21(WAF1/Cip1)), cell proliferation, cell cycle markers (cyclin D and cyclin A), and neural cell adhesion molecule (NCAM) was examined immunohistochemically in primary biliary cirrhosis (PBC, n = 37), chronic viral hepatitis (n = 39), nonalcoholic steatohepatitis (n = 25), and control normal livers (n = 12). The expression of p16(INK4a) and p21(WAF1/Cip1) was frequently found in ductular cells in the advanced stage of chronic liver diseases, especially in PBC (P < .05). Double immunostaining disclosed that most senescent cells expressed cyclin D (G(1)-phase marker). NCAM was frequently coexpressed in ductular cells showing senescence-associated markers. Some ductular cells in ductular reactions in chronic liver diseases were at G(1) arrest and undergoing cellular senescence. Such senescent cells may be involved in the progression of fibrosis of these diseases, particularly in PBC. |
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Authors:
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Motoko Sasaki; Hiroko Ikeda; Junpei Yamaguchi; Masami Miyakoshi; Yasunori Sato; Yasuni Nakanuma |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of clinical pathology Volume: 133 ISSN: 1943-7722 ISO Abbreviation: Am. J. Clin. Pathol. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-01-22 Completed Date: 2010-02-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370470 Medline TA: Am J Clin Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 212-23 Citation Subset: AIM; IM |
Affiliation:
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Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa 920-8640, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Bile Ducts, Intrahepatic
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pathology Biological Markers / analysis* Cell Aging* Cell Proliferation Cyclin D / metabolism Cyclin-Dependent Kinase Inhibitor p21 / metabolism Humans Keratin-7 / metabolism Liver / metabolism Liver Cirrhosis, Biliary / metabolism, pathology* Liver Diseases / metabolism, pathology* Neoplasm Proteins / metabolism Neural Cell Adhesion Molecules / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/CDKN1A protein, human; 0/Cyclin D; 0/Cyclin-Dependent Kinase Inhibitor p21; 0/Keratin-7; 0/Neoplasm Proteins; 0/Neural Cell Adhesion Molecules; 0/P16 protein, human |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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