Document Detail

Bile duct stone procedures are more frequent in patients with hypothyroidism. A large, registry-based, cohort study in Finland.
MedLine Citation:
PMID:  20030579     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Delayed bile flow may induce the formation/accumulation of common bile duct stones (CBDS). Bile flow is delayed in hypothyroidism, partly due to insufficient sphincter of Oddi relaxation. Patients with CBDS have higher incidences of clinical and subclinical hypothyroidism compared to healthy controls and gallbladder stone patients. The aim of this large registry-based study was to investigate the prevalence of CBDS in patients with diagnosed hypothyroidism compared to age-, sex- and living area-adjusted glaucoma (control) patients. MATERIAL AND METHODS: Between 1987 and 2001, all patients with approved Special Medical Coverage (SMC) for hypothyroidism or glaucoma, and without other SMC approvals, were included. The glaucoma (control) cohort was adjusted for age, sex and area of residence. For each patient, onset of SMC, all prescription drugs and treatments for CBDS were noted. RESULTS: A total of 14,334 patients in each group met the inclusion criteria. Thirty-three patients (0.23%) in the hypothyroidism cohort and 23 (0.16%) in the glaucoma cohort had been treated for CBDS (p = 0.018). The groups did not differ in the number of CBDS treatments before the diagnosis of hypothyroidism or glaucoma. However, after the diagnosis of hypothyroidism or glaucoma there were significantly more CBD stone patients in the hypothyroid cohort (n = 25) than in the glaucoma cohort (n = 14) (p < 0.05). CONCLUSIONS: Diagnosed hypothyroidism is a significant risk factor for CBDS. We hypothesize that CBD stone formation begins during the untreated period and develops/matures even after the medication has been initiated, raising the question of the efficiency of treatment in this respect. When treating CBDS patients, one should be aware of the possible hypothyroid background.
Johanna Laukkarinen; Juhani Sand; Ville Autio; Isto Nordback
Related Documents :
18302519 - The prevalence of transient thyrotoxicosis after antithyroid drug therapy in patients w...
6125279 - Effect of radioiodine on stimulatory activity of graves' immunoglobulins.
15251659 - Variations in adequate levothyroxine replacement therapy in patients with different cau...
17060029 - Thyroid peroxidase and thyroglobulin auto-antibodies in patients with newly diagnosed o...
8082149 - A study of thyroid dysfunction in nigerian psychiatric outpatients.
11745229 - Pretreatment prevalence of hypothyroidism in patients with head and neck carcinoma.
11339379 - Tetralogy of fallot associated with chromosome 22q11.2 deletion in adolescents and youn...
10530739 - Unilateral examination of olfactory threshold using the jet stream olfactometer.
12103259 - Vascular closure devices in patients treated with anticoagulation and iib/iiia receptor...
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian journal of gastroenterology     Volume:  45     ISSN:  1502-7708     ISO Abbreviation:  Scand. J. Gastroenterol.     Publication Date:  2010  
Date Detail:
Created Date:  2009-12-24     Completed Date:  2010-03-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0060105     Medline TA:  Scand J Gastroenterol     Country:  England    
Other Details:
Languages:  eng     Pagination:  70-4     Citation Subset:  IM    
Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aged, 80 and over
Cohort Studies
Gallstones / etiology*
Hypothyroidism / complications*
Middle Aged
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Liver transplantation of patients with cryptogenic cirrhosis: Clinical characteristics and outcome.
Next Document:  Extended lamivudine consolidation therapy in hepatitis B e antigen-positive chronic hepatitis B pati...