| Bile duct complications of hepatic arterial infusion chemotherapy evaluated by helical CT. | |
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MedLine Citation:
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PMID: 16038698 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To describe the imaging findings of bile duct complications of hepatic arterial infusion chemotherapy (HAIC) using helical CT, to set diagnostic criteria, to develop a CT grading system, and to correlate these with clinical findings and laboratory data. METHODS: Follow-up helical CT of the abdomen was performed every 3 months for 60 patients receiving HAIC. Three radiologists reviewed all CT studies before and after treatment, using either the picture archiving and communication system or hard copies. The findings of bile duct abnormalities were correlated with findings from other imaging techniques, clinical symptoms and laboratory data. RESULTS: Bile duct abnormalities developed in 34 (57%) of cases either during HAIC or 1 to 12 months after treatment. In 14 (41%) of these 34 patients, enhancement of the hepatic parenchyma along the dilated bile duct or in the segmental or lobar distribution was observed. In 43 cases (72%), normal or abnormal alkaline phosphatase levels were consistent with normal or abnormal CT findings, respectively. Increasing alkaline phosphatase and bilirubin levels were related to CT grade. CONCLUSION: Imaging findings of bile duct complications of HAIC are similar to those of primary sclerosing cholangitis, and correlate well with abnormal clinical and laboratory data. In the presence of such clinical abnormalities, thin-section helical CT with careful review of the imaging studies helps to determine the correct diagnosis, monitor the changes and guide appropriate treatment. |
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Authors:
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S Phongkitkarun; S Kobayashi; V Varavithya; X Huang; S A Curley; C Charnsangavej |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical radiology Volume: 60 ISSN: 0009-9260 ISO Abbreviation: Clin Radiol Publication Date: 2005 Jun |
Date Detail:
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Created Date: 2005-07-25 Completed Date: 2005-09-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1306016 Medline TA: Clin Radiol Country: England |
Other Details:
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Languages: eng Pagination: 700-9 Citation Subset: IM |
Affiliation:
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Department of Diagnostic Radiology, University of Texas M. D. Anderson Cancer Center, Houston, TX, USA. rasih@mahidol.ac.th |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma
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drug therapy,
radiography,
secondary Adult Aged Alkaline Phosphatase / blood Antineoplastic Agents / adverse effects*, therapeutic use Bile Duct Diseases / blood, etiology*, radiography* Bilirubin / blood Cholangiography / methods* Colorectal Neoplasms / complications, drug therapy, radiography Female Floxuridine / adverse effects, therapeutic use Follow-Up Studies Hepatic Artery* Humans Infusions, Intra-Arterial / adverse effects Liver Neoplasms / drug therapy, secondary Male Middle Aged Retrospective Studies Tomography, X-Ray Computed / methods* |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 50-91-9/Floxuridine; 635-65-4/Bilirubin; EC 3.1.3.1/Alkaline Phosphatase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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