Document Detail

Bile duct complications of hepatic arterial infusion chemotherapy evaluated by helical CT.
MedLine Citation:
PMID:  16038698     Owner:  NLM     Status:  MEDLINE    
AIM: To describe the imaging findings of bile duct complications of hepatic arterial infusion chemotherapy (HAIC) using helical CT, to set diagnostic criteria, to develop a CT grading system, and to correlate these with clinical findings and laboratory data. METHODS: Follow-up helical CT of the abdomen was performed every 3 months for 60 patients receiving HAIC. Three radiologists reviewed all CT studies before and after treatment, using either the picture archiving and communication system or hard copies. The findings of bile duct abnormalities were correlated with findings from other imaging techniques, clinical symptoms and laboratory data. RESULTS: Bile duct abnormalities developed in 34 (57%) of cases either during HAIC or 1 to 12 months after treatment. In 14 (41%) of these 34 patients, enhancement of the hepatic parenchyma along the dilated bile duct or in the segmental or lobar distribution was observed. In 43 cases (72%), normal or abnormal alkaline phosphatase levels were consistent with normal or abnormal CT findings, respectively. Increasing alkaline phosphatase and bilirubin levels were related to CT grade. CONCLUSION: Imaging findings of bile duct complications of HAIC are similar to those of primary sclerosing cholangitis, and correlate well with abnormal clinical and laboratory data. In the presence of such clinical abnormalities, thin-section helical CT with careful review of the imaging studies helps to determine the correct diagnosis, monitor the changes and guide appropriate treatment.
S Phongkitkarun; S Kobayashi; V Varavithya; X Huang; S A Curley; C Charnsangavej
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical radiology     Volume:  60     ISSN:  0009-9260     ISO Abbreviation:  Clin Radiol     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-07-25     Completed Date:  2005-09-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1306016     Medline TA:  Clin Radiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  700-9     Citation Subset:  IM    
Department of Diagnostic Radiology, University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.
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MeSH Terms
Adenocarcinoma / drug therapy,  radiography,  secondary
Alkaline Phosphatase / blood
Antineoplastic Agents / adverse effects*,  therapeutic use
Bile Duct Diseases / blood,  etiology*,  radiography*
Bilirubin / blood
Cholangiography / methods*
Colorectal Neoplasms / complications,  drug therapy,  radiography
Floxuridine / adverse effects,  therapeutic use
Follow-Up Studies
Hepatic Artery*
Infusions, Intra-Arterial / adverse effects
Liver Neoplasms / drug therapy,  secondary
Middle Aged
Retrospective Studies
Tomography, X-Ray Computed / methods*
Reg. No./Substance:
0/Antineoplastic Agents; 50-91-9/Floxuridine; 635-65-4/Bilirubin; EC Phosphatase

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