Document Detail


Bile acids: regulation of apoptosis by ursodeoxycholic acid.
MedLine Citation:
PMID:  19417220     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Bile acids are a group of molecular species of acidic steroids with peculiar physical-chemical and biological characteristics. At high concentrations they become toxic to mammalian cells, and their presence is pertinent in the pathogenesis of several liver diseases and colon cancer. Bile acid cytoxicity has been related to membrane damage, but also to nondetergent effects, such as oxidative stress and apoptosis. Strikingly, hydrophilic ursodeoxycholic acid (UDCA), and its taurine-conjugated form (TUDCA), show profound cytoprotective properties. Indeed, these molecules have been described as potent inhibitors of classic pathways of apoptosis, although their precise mode of action remains to be clarified. UDCA, originally used for cholesterol gallstone dissolution, is currently considered the first choice therapy for several forms of cholestatic syndromes. However, the beneficial effects of both UDCA and TUDCA have been tested in other experimental pathological conditions with deregulated levels of apoptosis, including neurological disorders, such as Alzheimer's, Parkinson's, and Huntington's diseases. Here, we review the role of bile acids in modulating the apoptosis process, emphasizing the anti-apoptotic effects of UDCA and TUDCA, as well as their potential use as novel and alternate therapeutic agents for the treatment of apoptosis-related diseases.
Authors:
Joana D Amaral; Ricardo J S Viana; Rita M Ramalho; Clifford J Steer; Cecília M P Rodrigues
Publication Detail:
Type:  Journal Article; Review     Date:  2009-05-05
Journal Detail:
Title:  Journal of lipid research     Volume:  50     ISSN:  0022-2275     ISO Abbreviation:  J. Lipid Res.     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-12-04     Completed Date:  2010-02-08     Revised Date:  2013-06-02    
Medline Journal Info:
Nlm Unique ID:  0376606     Medline TA:  J Lipid Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1721-34     Citation Subset:  IM    
Affiliation:
Research Institute for Medicines and Pharmaceutical Sciences, Faculty of Pharmacy, University of Lisbon, Lisbon, Portugal.
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MeSH Terms
Descriptor/Qualifier:
Animals
Apoptosis / drug effects*
Bile Acids and Salts / metabolism,  pharmacology*,  therapeutic use
Humans
Signal Transduction / drug effects
Ursodeoxycholic Acid / metabolism,  pharmacology*,  therapeutic use
Chemical
Reg. No./Substance:
0/Bile Acids and Salts; 128-13-2/Ursodeoxycholic Acid
Comments/Corrections

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