| Bile acids influence hepatic chemiluminescence in normal and oxidative-stressed rats. | |
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MedLine Citation:
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PMID: 9737577 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of the present study was to clarify whether bile acids influence chemiluminescence (CL) in the liver in vivo. Hepatic CL was determined on the surface of the liver of anaesthetized rats by using a photon counter. In normal rats, hepatic CL was significantly decreased 30 min after enteral administration of chenodeoxycholic acid (CDCA) or deoxycholic acid (DCA), but returned to its initial level 3 h later, after part of the CDCA administered was metabolized. Ursodeoxycholic acid (UDCA) and cholic acid had no effect on CL. In contrast, hepatic CL was markedly increased 30 min after CDCA or DCA administration in rats given either buthionine sulphoximine (BSO), an inhibitor of gamma-glutamylcysteine synthetase, or diethyldithiocarbamate (DDC), an inhibitor of both superoxide dismutase and glutathione peroxidase. Chenodeoxycholic acid further increased the CL of BSO- or DDC-treated rats during inhalation of oxygen via a tracheal cannula. Coadministration of UDCA eliminated the effects of CDCA on the hepatic CL of normal and BSO- or DDC-treated rats with or without oxygen inhalation. We conclude that cytotoxic bile acids, such as CDCA, increase CL in the antioxidants-depleted or oxidative-stressed liver in vivo, but that UDCA prevents CDCA from developing CL. |
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Authors:
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T Nakashima; N Matsumoto; Y Nakajima; H Ishikawa; H Mitsuyoshi; K Inaba; M Sakai; Y Sakamoto; M Matsumoto; T Shima; K Kashima; T Kitayoshi; N Shimamoto |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of gastroenterology and hepatology Volume: 13 ISSN: 0815-9319 ISO Abbreviation: J. Gastroenterol. Hepatol. Publication Date: 1998 Jan |
Date Detail:
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Created Date: 1998-11-10 Completed Date: 1998-11-10 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8607909 Medline TA: J Gastroenterol Hepatol Country: AUSTRALIA |
Other Details:
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Languages: eng Pagination: 81-7 Citation Subset: IM |
Affiliation:
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Third Department of Internal Medicine, Kyoto Prefectural University of Medicine, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bile Acids and Salts / metabolism*, pharmacology Chemiluminescent Measurements* Glutathione / metabolism Lipid Peroxidation Liver / metabolism*, pathology Male Oxidative Stress* Rats Rats, Wistar |
| Chemical | |
Reg. No./Substance:
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0/Bile Acids and Salts; 70-18-8/Glutathione |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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