Document Detail

Bile acids in experimental colorectal cancer.
MedLine Citation:
PMID:  3729259     Owner:  NLM     Status:  MEDLINE    
Cogent epidemiological and experimental data implicate bile acids as endogenous co-carcinogens in colorectal cancer. A series of experiments was designed to test the ability of sodium deoxycholate (SDC) to promote intestinal hyperplasia and neoplasia in rats (n = 265). The intermediary role of faecal anaerobes was explored in animals receiving oral metronidazole. Intrarectal instillation of SDC trebled tumour yield in functioning large bowel and increased both crypt depth and crypt cell production rate. Metronidazole reduced this tumour promotion without affecting SDC-induced hyperplasia. By contrast, SDC was totally inactive in colon isolated as a Thiry-Vella fistula. Bile acids probably promote colorectal carcinogenesis by stimulating mucosal hyperplasia but only in the presence of faeces.
J B Rainey
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of the Royal College of Surgeons of England     Volume:  68     ISSN:  0035-8843     ISO Abbreviation:  Ann R Coll Surg Engl     Publication Date:  1986 May 
Date Detail:
Created Date:  1986-08-20     Completed Date:  1986-08-20     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7506860     Medline TA:  Ann R Coll Surg Engl     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  130-3     Citation Subset:  IM    
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MeSH Terms
Colonic Neoplasms / chemically induced*,  microbiology
Deoxycholic Acid / toxicity*
Feces / microbiology
Metronidazole / pharmacology
Rats, Inbred Strains
Rectal Neoplasms / chemically induced*,  microbiology
Reg. No./Substance:
443-48-1/Metronidazole; 83-44-3/Deoxycholic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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