Document Detail

Bile acids and gut peptide secretion after bariatric surgery - A 1-year prospective randomized pilot trial.
MedLine Citation:
PMID:  23804517     Owner:  NLM     Status:  Publisher    
Objective: Increased delivery of bile acid salts (BA) to distal L-cells and altered TGR5 receptor activation may contribute to the early and substantial increases in gut peptide secretion seen after bariatric surgery. To further elucidate a potential role of BA in the secretion of GLP-1 and PYY, we analyzed plasma BA concentrations in 14 morbidly obese patients undergoing gastric bypass or sleeve gastrectomy in a prospective, randomized 1-year trial. Design and Methods: Patients received a standard test meal and blood was collected before and after eating, prior to, and 1 week, 3 months, and 12 months after surgery. Results: Pre-surgery, basal BA concentrations were significantly lower in bariatric patients than in healthy controls. One year post-surgery, bariatric patients expressed variably increased BA concentrations (gastric bypass patients ˜2 fold increase, p≤0.05). However, whereas in both patient groups, marked increases in GLP-1 and PYY and improved glycemic control was seen already 1 week and 3 months post-surgery, changes in plasma BA followed a different pattern - basal and postprandial plasma BA concentrations increased much slower, more progressively with significant increases only 1 year post-surgery. Conclusions: Based on these findings, BA do not appear to be key mediators of the early increase in GLP-1 and PYY response in postbariatric patients.
Robert E Steinert; Ralph Peterli; Sylvia Keller; Anne C Meyer-Gerspach; Jürgen Drewe; Thomas Peters; Christoph Beglinger
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-6-26
Journal Detail:
Title:  Obesity (Silver Spring, Md.)     Volume:  -     ISSN:  1930-739X     ISO Abbreviation:  Obesity (Silver Spring)     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-6-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101264860     Medline TA:  Obesity (Silver Spring)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 The Obesity Society.
Department of Biomedicine and Division of Gastroenterology, University Hospital Basel, Switzerland.
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