Document Detail


Bile acids and colon cancer: Solving the puzzle with nuclear receptors.
MedLine Citation:
PMID:  21724466     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Colorectal cancer is the third most common malignancy worldwide and is often linked to obesity, a sedentary lifestyle, carbohydrate- and fat-rich diets and elevated fecal excretion of secondary bile acids. Accumulation of toxic bile acids triggers oxidative damage, mitochondrial dysfunction and tumor progression. Nuclear receptors are transcription factors crucially involved in the regulation of bile acid metabolism and detoxification, and their activation may confer protection from bile acid tumor-promoting activity. In this review, we explore the tangled relationships among bile acids, nuclear receptors and the intestinal epithelium, with particular emphasis on the role of the farnesoid X receptor in colorectal cancer prevention and on novel nuclear receptor-based approaches to expand the portfolio of chemotherapeutic agents.
Authors:
Chiara Degirolamo; Salvatore Modica; Giuseppe Palasciano; Antonio Moschetta
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2011-07-02
Journal Detail:
Title:  Trends in molecular medicine     Volume:  17     ISSN:  1471-499X     ISO Abbreviation:  Trends Mol Med     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-07     Completed Date:  2012-01-23     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  100966035     Medline TA:  Trends Mol Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  564-72     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Bile Acids and Salts / genetics,  metabolism*
Colon / metabolism
Colonic Neoplasms / genetics,  metabolism*
Gene Expression Regulation, Neoplastic
Humans
Intestinal Mucosa / metabolism
Receptors, Cytoplasmic and Nuclear / genetics,  metabolism*
Grant Support
ID/Acronym/Agency:
GGP08259//Telethon
Chemical
Reg. No./Substance:
0/Bile Acids and Salts; 0/Receptors, Cytoplasmic and Nuclear; 0/farnesoid X-activated receptor

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