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Bile acids, chaperones, and Mammalian longevity.
MedLine Citation:
PMID:  22533434     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Abstract Bile acids are detergent molecules derived from cholesterol in the liver that are important for the metabolism and absorption of lipids in the intestine. Bile acids are also steroid hormones activating specific nuclear receptors and G protein-coupled receptors. Conjugated bile acids are cytoprotective and anticarcinogenic. Bile acid synthesis and bile flow decreases markedly during aging. The housekeeping molecular chaperones are stress response proteins, important for the processes of folding, maintenance, and repair of proteins, RNA, and DNA, as well as for the structure and function of the steroid hormone receptors. The level of expression of the molecular chaperones correlates with mammalian longevity as well as with the life span of differentiated cells. The functions of the chaperone machinery are progressively impaired during aging, and the progressive age-related impairment of these housekeeping mechanisms probably contributes to the phenotype of aging. This review presents evidence that the bile acids are chemical chaperones, improving the general chaperone defense, and thus serve to support an epigenetic mechanism of possible significance for the evolution of mammalian longevity, as well as for the attainment of healthy aging.
Authors:
Jens Krøll
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Rejuvenation research     Volume:  15     ISSN:  1557-8577     ISO Abbreviation:  Rejuvenation Res     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-04-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101213381     Medline TA:  Rejuvenation Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  210-2     Citation Subset:  IM    
Affiliation:
Hafnia Unit of Biogerontology , Frederiksberg, Denmark .
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