| Bile acid transport in the anhepatic rat. | |
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MedLine Citation:
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PMID: 1499904 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hepatocyte dysfunction eventually results in the loss of canalicular bile formation. Without canalicular flow, intestinal bile acid may originate from plasma by reverse transport. Anhepatic rats with preserved intestinal function permit evaluation of such transport. In the present study, plasma taurocholate clearance was markedly decreased in anhepatic rats. The relative proportion of free cholate increased with time. Peripheral tissues contained virtually only cleared taurocholate, but the intestinal contents were mainly free cholate. This indicates the intestinal contents as the source of the plasma cholate and shows an equilibrium between intestinal and plasma bile acid even without bile flow. The enteral administration of an anion exchange resin to anhepatic rats increased intestinal bile acid recovery and decreased the bile acid recovery in tissue. Plasma bile acid concentration was decreased and fractional loss increased threefold, confirming the anhepatic plasma-intestine bile acid equilibrium. However, the enhanced plasma clearance produced by the resin was less than 1% of the fractional loss found in the intact rat. These data show a very limited bile acid flux between intestine and plasma without bile flow, which could be modestly influenced by an intestinal bile acid sequestrant. |
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Authors:
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G Cucchiaro; W C Meyers; S L Young; G D Branum; S Quarfordt |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Gastroenterology Volume: 103 ISSN: 0016-5085 ISO Abbreviation: Gastroenterology Publication Date: 1992 Sep |
Date Detail:
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Created Date: 1992-09-15 Completed Date: 1992-09-15 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0374630 Medline TA: Gastroenterology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1034-40 Citation Subset: AIM; IM |
Affiliation:
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Department of Surgery, Duke University Medical Center, Durham, North Carolina. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bile Acids and Salts / metabolism*, pharmacokinetics Enterohepatic Circulation Hepatectomy* Male Rats Rats, Inbred Strains Taurocholic Acid / metabolism, pharmacokinetics Tissue Distribution |
| Grant Support | |
ID/Acronym/Agency:
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2 R01 DK35490/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Bile Acids and Salts; 81-24-3/Taurocholic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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