Document Detail

Bile acid structure and bile formation: a comparison of hydroxy and keto bile acids.
MedLine Citation:
PMID:  7356024     Owner:  NLM     Status:  MEDLINE    
The effect of four bile acids, taurocholic (TC), taurochenodeoxycholic (TCDC), tauro-3 alpha,7 alpha-dihydroxy-12-keto-5 beta-cholanoic (T12K), and cholic (C), on bile lipid and water secretion was studied in the bile fistula cat over a 20-fold range of bile acid secretion rates. The critical micellar concentration (CMC) and lecithin-solubilizing capacity of TC, TCDC, and T12K were measured in vitro. T12K and C produced a greater choleresis than TC or TCDC; phospholipid secretion was strikingly reduced with T12K; and cholesterol secretion strikingly increased with TCDC, with a high cholesterol-phospholipid ratio. The estimated CMCs of TC, TCDC, and T12K were 3.3, 0.7, and 6.2 mM respectively; the relative lecithin-solubilizing capacities were 4.4:2.6:1. We conclude that the micellar characteristics of the bile acids studied do not explain the differences in water and lipid secretion observed, and that effects within the hepatocyte may be equally important.
R B Sewell; N E Hoffman; R A Smallwood; S Cockbain
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of physiology     Volume:  238     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1980 Jan 
Date Detail:
Created Date:  1980-04-25     Completed Date:  1980-04-25     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  G10-7     Citation Subset:  IM    
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MeSH Terms
Bile / secretion*
Bile Acids and Salts / administration & dosage,  pharmacology*
Body Water / secretion*
Cholesterol / secretion*
Cholic Acids / pharmacology
Infusions, Parenteral
Phosphatidylcholines / secretion*
Phospholipids / secretion*
Taurocholic Acid / pharmacology
Reg. No./Substance:
0/Bile Acids and Salts; 0/Cholic Acids; 0/Phosphatidylcholines; 0/Phospholipids; 57-88-5/Cholesterol; 81-24-3/Taurocholic Acid

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