Document Detail

Bile acid promotes intestinal metaplasia and gastric carcinogenesis.
MedLine Citation:
PMID:  23010643     Owner:  NLM     Status:  Publisher    
BACKGROUND: Bile acid and Helicobacter pylori are important toxic factors for gastric mucosal injury. We examined the role of bile acid in promoting histological gastritis and gastric carcinoma in Japanese patients. METHODS: A total of 767 patients (452 men, mean age 51.1 y.o.) were studied. Gastric juice was collected by gastro-endoscopic examination, and the bile acid concentration was examined by enzymatic method. The grade of histological gastritis was evaluated by gastric biopsies, and the relationship between the bile acid concentration and the gastritis score was examined. The occurrence of gastric cancer was examined by a retrospective cohort study. CDX2/CINC1 expression in RGM-1 cells was evaluated by real-time PCR. RESULTS: In H. pylori-positive patients, we found significant positive correlation between the bile acid concentration and the grades of atrophy/intestinal metaplasia (P<0.01). However, we found significant negative associations between the bile acid concentrations and the histological scores of mononuclear cell/neutrophil infiltrations (P<0.01). Patients with a high concentration of bile acid developed gastric cancer more frequently than those with a low concentration (P<0.05). Cholic acid treatment significantly increased CDX2 expression in RGM-1 cells. CINC1 expression in RGM-1 cell was significantly induced by co-culture with H. pylori and the induction was reduced by glycochenodeoxycholic acid treatment. CONCLUSION: The bile acid in gastric juice contributes to the progression of histological atrophy and intestinal metaplasia without inflammatory cell infiltration, followed by carcinogenesis in H. pylori-positive patients. Impact: Bile acid promotes intestinal metaplasia and gastric carcinogenesis without inflammatory cell infiltration.
Masana Tatsugami; Masanori Ito; Shinji Tanaka; Masaharu Yoshihara; Hirofumi Matui; Ken Haruma; Kazuaki Chayama
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-25
Journal Detail:
Title:  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology     Volume:  -     ISSN:  1538-7755     ISO Abbreviation:  Cancer Epidemiol. Biomarkers Prev.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9200608     Medline TA:  Cancer Epidemiol Biomarkers Prev     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1Department of Medicine and Molecular Science, Hiroshima University.
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