Document Detail

Bile acid metabolism in the pig.
MedLine Citation:
PMID:  3698597     Owner:  NLM     Status:  MEDLINE    
To study bile acid metabolism in the pig, indwelling catheters were surgically placed in the hepatic portal vein and the anterior vena cava of 12-17 kg crossbred pigs. The pigs were fed ad libitum for one hr at 0800 and 1600 hrs daily. Two weeks after the surgery, 50 microCi of 24[14C] chenodeoxycholic acid were infused into the hepatic portal vein. The radioactivity in plasma from the two veins was monitored hourly for six hrs following each of six consecutive meals over a 3-day period. Fecal and urine radioactivity were determined for 14 days. It was found that the peak levels of radioactivity in the plasma of both veins were reached within two hrs post-feeding. The biological half-life of chenodeoxycholic acid was determined to be 6.4 days.
J D Tracy; A H Jensen; R V Allhands
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Cornell veterinarian     Volume:  76     ISSN:  0010-8901     ISO Abbreviation:  Cornell Vet     Publication Date:  1986 Apr 
Date Detail:
Created Date:  1986-06-03     Completed Date:  1986-06-03     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0074245     Medline TA:  Cornell Vet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  128-38     Citation Subset:  IM    
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MeSH Terms
Chenodeoxycholic Acid / blood,  metabolism*
Feces / analysis
Portal Vein
Swine / metabolism*
Time Factors
Venae Cavae
Reg. No./Substance:
474-25-9/Chenodeoxycholic Acid

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