Document Detail

Bile acid dissolution therapy of gallbladder stones.
MedLine Citation:
PMID:  1486209     Owner:  NLM     Status:  MEDLINE    
Oral cholelitholytic bile acid therapy has become established treatment for selected patients with cholesterol gallstones. The treatment finds its clinical application both alone and in combination with ESWL. UDCA alone or, less commonly, a combination of this bile acid with CDCA is used. Optimal results can be expected only in carefully selected patients. Bile acid dissolution therapy is most successful in patients with radiolucent gallstones which are < or = 0.5 cm in diameter or are shown by OCG to be floating. Dissolution is seldom seen when the stones are > 1 cm in size. Cholelitholytic treatment in combination with ESWL yields optimal results in single radiolucent gallstones which are not greater than 2 cm. ESWL thus makes it possible to use medical treatment effectively in single 1-2 cm gallstones when bile acids alone would not be successful. Bile acid treatment is extremely safe, especially if UDCA is given without the addition of CDCA.
H Fromm; M Malavolti
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Baillière's clinical gastroenterology     Volume:  6     ISSN:  0950-3528     ISO Abbreviation:  Baillieres Clin. Gastroenterol.     Publication Date:  1992 Nov 
Date Detail:
Created Date:  1993-02-25     Completed Date:  1993-02-25     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8704786     Medline TA:  Baillieres Clin Gastroenterol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  689-95     Citation Subset:  IM    
Department of Medicine, George Washington Medical Centre, Washington, DC 20037.
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MeSH Terms
Chenodeoxycholic Acid / therapeutic use
Cholelithiasis / therapy*
Combined Modality Therapy
Ursodeoxycholic Acid / therapeutic use*
Reg. No./Substance:
128-13-2/Ursodeoxycholic Acid; 474-25-9/Chenodeoxycholic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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