Document Detail


Bile acid changes after high-dose ursodeoxycholic acid treatment in primary sclerosing cholangitis: Relation to disease progression.
MedLine Citation:
PMID:  20564380     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CONCLUSION: High-dose UDCA treatment in PSC patients results in marked UDCA enrichment and significant expansion of the total serum bile acid pool, including LCA.
Authors:
Emmanouil Sinakos; Hanns-Ulrich Marschall; Kris V Kowdley; Alex Befeler; Jill Keach; Keith Lindor
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  52     ISSN:  1527-3350     ISO Abbreviation:  Hepatology     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-01     Completed Date:  2010-07-19     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  197-203     Citation Subset:  IM    
Affiliation:
Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, USA.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Bile Acids and Salts / blood*
Cholagogues and Choleretics / administration & dosage*,  blood
Cholangitis, Sclerosing / blood,  drug therapy*
Disease Progression
Dose-Response Relationship, Drug
Double-Blind Method
Female
Humans
Lithocholic Acid / blood
Male
Middle Aged
Randomized Controlled Trials as Topic
Treatment Outcome
Ursodeoxycholic Acid / administration & dosage*,  blood
Young Adult
Grant Support
ID/Acronym/Agency:
DK56924/DK/NIDDK NIH HHS; R01 DK056924-05/DK/NIDDK NIH HHS; R01 DK056924-10/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Bile Acids and Salts; 0/Cholagogues and Choleretics; 128-13-2/Ursodeoxycholic Acid; 434-13-9/Lithocholic Acid
Comments/Corrections

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