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Bile Acids Affect the Growth of Human Cholangiocarcinoma via NF-kB Pathway.
MedLine Citation:
PMID:  23362950     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
We observed that free bile acids (CA, DCA, and CDCA) inhibited the growth of cholangiocarcinoma cells by promoting cell apoptosis, while the conjugated bile acids (GCA, GDCA, and GCDCA) stimulated cell growth. Consistently, we found that GDCA stimulated tumor growth and CDCA decreased tumor growth in xenografted mice. Further, the phosphorylated IkB was downregulated by free bile acids, and was upregulated by the conjugated bile acids. IL-6 and COX-2 were decreased by the free bile acids and increased by the conjugated bile acids. Collectively, these results suggest that the bile acids regulate the growth of cholangiocarcinoma by modulating NF-kB pathway.
Authors:
Jiaqi Dai; Hongxia Wang; Ying Dong; Yinxin Zhang; Jian Wang
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cancer investigation     Volume:  31     ISSN:  1532-4192     ISO Abbreviation:  Cancer Invest.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8307154     Medline TA:  Cancer Invest     Country:  England    
Other Details:
Languages:  eng     Pagination:  111-20     Citation Subset:  IM    
Affiliation:
Divisions of General Surgery,1.
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