| Bile Acids Affect the Growth of Human Cholangiocarcinoma via NF-kB Pathway. | |
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MedLine Citation:
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PMID: 23362950 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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We observed that free bile acids (CA, DCA, and CDCA) inhibited the growth of cholangiocarcinoma cells by promoting cell apoptosis, while the conjugated bile acids (GCA, GDCA, and GCDCA) stimulated cell growth. Consistently, we found that GDCA stimulated tumor growth and CDCA decreased tumor growth in xenografted mice. Further, the phosphorylated IkB was downregulated by free bile acids, and was upregulated by the conjugated bile acids. IL-6 and COX-2 were decreased by the free bile acids and increased by the conjugated bile acids. Collectively, these results suggest that the bile acids regulate the growth of cholangiocarcinoma by modulating NF-kB pathway. |
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Authors:
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Jiaqi Dai; Hongxia Wang; Ying Dong; Yinxin Zhang; Jian Wang |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cancer investigation Volume: 31 ISSN: 1532-4192 ISO Abbreviation: Cancer Invest. Publication Date: 2013 Feb |
Date Detail:
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Created Date: 2013-01-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8307154 Medline TA: Cancer Invest Country: England |
Other Details:
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Languages: eng Pagination: 111-20 Citation Subset: IM |
Affiliation:
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Divisions of General Surgery,1. |
Export Citation:
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Descriptor/Qualifier:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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