Document Detail

Bilateral xanthine nephrolithiasis in a dog.
MedLine Citation:
PMID:  9239633     Owner:  NLM     Status:  MEDLINE    
Xanthinuria is an uncommon metabolic disorder clinically manifested as urolithiasis. There are two forms of the disease, congenital and iatrogenic. The former was diagnosed in a four-year-old dachshund bitch. The patient was presented with signs of terminal chronic renal failure. Urine was bacteriologically sterile with massive amorphous crystalluria. Bilateral nephrolithiasis was diagnosed at necropsy. The kidneys were shrunken with marked atrophy of the renal cortex and medulla. Infrared spectrometry revealed that the stones comprised 100 per cent xanthine. Later, two of the patient's siblings were examined for urine xanthine content; both showed higher concentrations of xanthine than a control dog. The described case is compared with seven known published cases of congenital xanthinuria.
J Kucera; T Bulková; R Rychlá; P Jahn
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Journal of small animal practice     Volume:  38     ISSN:  0022-4510     ISO Abbreviation:  J Small Anim Pract     Publication Date:  1997 Jul 
Date Detail:
Created Date:  1997-10-16     Completed Date:  1997-10-16     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0165053     Medline TA:  J Small Anim Pract     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  302-5     Citation Subset:  IM    
Clinic of Small Animal Internal Medicine, Faculty of Veterinary Medicine, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic.
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MeSH Terms
Dog Diseases / congenital,  diagnosis*,  urine
Kidney Calculi / chemistry*,  pathology,  urine
Kidney Cortex / pathology
Kidney Failure, Chronic / complications,  veterinary
Kidney Medulla / pathology
Spectrophotometry, Infrared / methods,  veterinary
Xanthines / analysis*,  urine
Reg. No./Substance:
0/Xanthines; 69-89-6/Xanthine

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