Document Detail


Bilateral vertebral artery dissection, agenesis of both ICAs, and connective tissue aberrations.
MedLine Citation:
PMID:  23568999     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
A 35-year-old woman presented with acute signs of stroke (appendix e-1 on the Neurology® Web site at www.neurology.org). After initial CT with angiography, MRI with time-of-flight angiography confirmed agenesis of both internal carotid arteries (ICA; figure 1A). It revealed bilateral vertebral artery (VA) dissections and ischemias in both middle artery territories (figure 1, A-E). Skin biopsy microscopy (figure 2) was consistent with ultrastructural connective tissue syndrome (uCTD), for which no further evidence was found apart from mild hypermobility of the finger joints. The underlying uCTD with structural instability of the arterial walls and, due to the bilateral ICA agenesis, the increased blood flow in the vertebrobasilar circulation may have promoted VA dissection.
Authors:
Christina M Lill; Kristin Günther-Kunkel; Heinrich Hoch; Friedemann Paul; Caspar Grond-Ginsbach; Ingrid Hausser; Frauke Zipp
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Neurology     Volume:  80     ISSN:  1526-632X     ISO Abbreviation:  Neurology     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-4-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1442-1443     Citation Subset:  -    
Affiliation:
From the Rhine Main Neuroscience Network (rmn2), Johannes Gutenberg University Center, Department of Neurology (C.M.L., F.Z.), Mainz; Neuropsychiatric Genetics Group, Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics (C.M.L.), Berlin; Institute for Neuroradiology, Helios-Klinikum Berlin-Buch (K.G.-K., H.H.), Berlin; Charité-University Medicine Berlin (F.P.), Berlin; Department of Neurology (C.G.-G.), the Department of Dermatology and Electron Microscopy Core Facility (I.H.), University of Heidelberg, Heidelberg, Germany.
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