Document Detail

Bilateral subthalamic nucleus stimulation for generalized dystonia after bilateral pallidotomy.
MedLine Citation:
PMID:  23038611     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Thalamotomies and pallidotomies were commonly performed before the deep brain stimulation (DBS) era. Although ablative procedures can lead to significant dystonia improvement, longer periods of analysis reveal disease progression and functional deterioration. Today, the same patients seek additional treatment possibilities.
METHODS: Four patients with generalized dystonia who previously had undergone bilateral pallidotomy came to our service seeking additional treatment because of dystonic symptom progression. Bilateral subthalamic nucleus DBS (B-STN-DBS) was the treatment of choice. The patients were evaluated with the Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS) and the Unified Dystonia Rating Scale (UDRS) before and 2 years after surgery.
RESULTS: All patients showed significant functional improvement, averaging 65.3% in BFMDRS (P = .014) and 69.2% in UDRS (P = .025).
CONCLUSIONS: These results suggest that B-STN-DBS may be an interesting treatment option for generalized dystonia, even for patients who have already undergone bilateral pallidotomy.
Erich Talamoni Fonoff; Wuilker Knoner Campos; Maurício Mandel; Eduardo Joaquim Lopes Alho; Manoel Jacobsen Teixeira
Publication Detail:
Type:  Journal Article     Date:  2012-10-04
Journal Detail:
Title:  Movement disorders : official journal of the Movement Disorder Society     Volume:  27     ISSN:  1531-8257     ISO Abbreviation:  Mov. Disord.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-19     Completed Date:  2013-04-18     Revised Date:  2013-10-02    
Medline Journal Info:
Nlm Unique ID:  8610688     Medline TA:  Mov Disord     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1559-63     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Movement Disorder Society.
Division of Functional Neurosurgery, Department of Neurology of School of Medicine of University of São Paulo, São Paulo SP, Brazil.
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MeSH Terms
Deep Brain Stimulation / methods*
Dystonic Disorders / therapy*
Functional Laterality
Middle Aged
Pallidotomy / methods*
Subthalamic Nucleus / physiology*
Treatment Outcome
Young Adult
Comment In:
Mov Disord. 2013 Jul;28(8):1163-4   [PMID:  23580315 ]
Mov Disord. 2013 Jul;28(8):1162-3   [PMID:  23580321 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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