| Bilateral subthalamic nucleus deep brain stimulation for dopa-responsive dystonia in a 6-year-old child. | |
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MedLine Citation:
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PMID: 21631204 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Tyrosine hydroxylase (TH) deficiency is a rare autosomal recessive metabolic disease that results in the decreased production of catecholamines. Standard treatment relies on combinations of levodopa and carbidopa, anticholinergic agents, serotonergic agonists, and monamine oxidase B inhibitors. Unfortunately, severely affected children often require escalating doses of medication and suffer from dyskinesias as well as significant on/off symptomatology. The authors present a case of medically intractable dopa-responsive dystonia in a 6-year-old boy whose condition significantly improved with bilateral subthalamic nucleus deep brain stimulation. This case is unique in its novel approach to tyrosine hydroxylase deficiency and the young age of the patient. |
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Authors:
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Matthew J Tormenti; Nestor D Tomycz; Keith A Coffman; Douglas Kondziolka; Donald J Crammond; Elizabeth C Tyler-Kabara |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of neurosurgery. Pediatrics Volume: 7 ISSN: 1933-0715 ISO Abbreviation: J Neurosurg Pediatr Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-06-02 Completed Date: 2011-08-19 Revised Date: 2011-12-13 |
Medline Journal Info:
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Nlm Unique ID: 101463759 Medline TA: J Neurosurg Pediatr Country: United States |
Other Details:
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Languages: eng Pagination: 650-3 Citation Subset: IM |
Affiliation:
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UPMC Center for Brain Function and Behavior, Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Child Deep Brain Stimulation* / methods Dyskinesias / congenital, therapy* Dystonic Disorders / congenital, physiopathology, therapy Humans Male Subthalamic Nucleus / physiopathology* Treatment Outcome |
| Comments/Corrections | |
Erratum In:
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J Neurosurg Pediatr. 2011 Nov;8(5):536 Note: Crammond, Donald J [added] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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