Document Detail

Bilateral stimulation of the caudal zona incerta nucleus for tremor control.
MedLine Citation:
PMID:  18037630     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: The ventrolateral (VL) nucleus of the thalamus is the commonly chosen target for deep brain stimulation (DBS) to alleviate tremor. However, it has a poor efficacy in alleviating proximal tremor and patients may develop tolerance to the action component of tremor. We performed bilateral stimulation of the caudal or motor part of the zona incerta nucleus (cZI) to determine its safety and efficacy in alleviating tremor.
METHODS: 5 patients with parkinsonian tremor and 13 with a range of tremors (Holmes (HT), cerebellar (CT), essential (ET), multiple sclerosis (MS) and dystonic tremor (DT)) affecting both the proximal and distal body parts underwent MRI guided, bilateral cZI DBS. Tremor was assessed by the Fahn-Tolosa-Marin (FTM) tremor scale at baseline and at a mean follow-up of 12 months.
RESULTS: Resting PD tremor improved by 94.8% and postural tremor by 88.2%. The total tremor score improved by 75.9% in 6 patients with ET. HT improved by 70.2%, proximal CT by 60.4% and proximal MS tremor by 57.2% in the total tremor rating score. In the single patient with DT, there was improvement in both the dystonia and the tremor. Patients required low voltages of high-frequency stimulation and did not develop tolerance to it. Stimulation-related side effects were transient.
CONCLUSION: This prospective study shows that the cZI may be an alternative target for the treatment of tremor with DBS. In contrast to bilateral DBS of the VL nucleus, it improves all components of tremor affecting both the distal and proximal limbs as well as the axial musculature.
P Plaha; S Khan; S S Gill
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-11-23
Journal Detail:
Title:  Journal of neurology, neurosurgery, and psychiatry     Volume:  79     ISSN:  1468-330X     ISO Abbreviation:  J. Neurol. Neurosurg. Psychiatr.     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-04-14     Completed Date:  2008-04-29     Revised Date:  2014-03-17    
Medline Journal Info:
Nlm Unique ID:  2985191R     Medline TA:  J Neurol Neurosurg Psychiatry     Country:  England    
Other Details:
Languages:  eng     Pagination:  504-13     Citation Subset:  IM    
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MeSH Terms
Aged, 80 and over
Deep Brain Stimulation*
Dominance, Cerebral / physiology*
Dystonia / physiopathology,  therapy
Middle Aged
Multiple Sclerosis / physiopathology,  therapy
Neurologic Examination
Parkinson Disease / physiopathology,  therapy
Prospective Studies
Stereotaxic Techniques
Subthalamus / physiopathology*
Tremor / etiology,  physiopathology,  therapy*
Ventral Thalamic Nuclei / physiopathology
Grant Support
G-4030//Parkinson's UK; G9900797//Medical Research Council

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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