Document Detail


Bilateral splanchnicotomy does not affect lipopolysaccharide-induced fever in rats.
MedLine Citation:
PMID:  14642851     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Intraperitoneal capsaicin desensitizes sensory fibers traveling within both the vagus and splanchnic nerves. Because capsaicin desensitization blocks the first phase of lipopolysaccharide (LPS) fever, whereas surgical vagotomy does not, splanchnic mediation of the first phase was proposed. However, all phases of the febrile response of splanchnicotomized rats to intravenous LPS (10 microg/kg) were similar to those of sham-operated controls. Hence, the splanchnic nerve is likely uninvolved in LPS fever.
Authors:
M Devrim Dogan; Vladimir A Kulchitsky; Shreya Patel; Erika Pétervári; Miklós Székely; Andrej A Romanovsky
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Brain research     Volume:  993     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2003-12-03     Completed Date:  2004-02-12     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  227-9     Citation Subset:  IM    
Affiliation:
Systemic Inflammation Laboratory, Trauma Research, St. Joseph's Hospital and Medical Center, 350 West Thomas Road, Phoenix, AZ 85013, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Temperature / physiology
Disease Models, Animal
Fever / chemically induced,  physiopathology*
Lipopolysaccharides*
Male
Rats
Rats, Long-Evans
Splanchnic Nerves / surgery*
Vagotomy / methods
Grant Support
ID/Acronym/Agency:
NS-41233/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Lipopolysaccharides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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